SLC8A3 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC8A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC8A3
  * **<color #00a2e8>Official Name</color>**: solute carrier family 8 member A3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6547|6547]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P57103|P57103]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC8A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC8A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607991|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity). {ECO:0000250|UniProtKB:S4R2P9, ECO:0000269|PubMed:21959935}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Na Ca ex|
|Calx-beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration|
|ion antiporter activity involved in regulation of postsynaptic membrane potential|
|calcium ion export across plasma membrane|
|calcium:sodium antiporter activity|
|calcium ion export|
|calcium ion import across plasma membrane|
|sarcoplasm|
|calcium ion import into cytosol|
|regulation of postsynaptic cytosolic calcium ion concentration|
|regulation of skeletal muscle contraction|
|mitochondrial calcium ion transmembrane transport|
|mitochondrial calcium ion homeostasis|
|intrinsic component of plasma membrane|
|export across plasma membrane|
|calcium ion import|
|integral component of postsynaptic membrane|
|long-term synaptic potentiation|
|cellular response to cAMP|
|calcium ion transmembrane import into cytosol|
|regulation of cardiac conduction|
|oligodendrocyte differentiation|
|calcium ion transport into cytosol|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|neuromuscular junction|
|hematopoietic progenitor cell differentiation|
|cytosolic calcium ion transport|
|sodium ion transmembrane transport|
|regulation of striated muscle contraction|
|import across plasma membrane|
|sarcolemma|
|response to cAMP|
|myelination|
|ensheathment of neurons|
|axon ensheathment|
|memory|
|perikaryon|
|response to organophosphorus|
|learning|
|dendritic spine|
|positive regulation of synaptic transmission|
|response to purine-containing compound|
|sodium ion transport|
|regulation of muscle contraction|
|mitochondrial outer membrane|
|glial cell differentiation|
|cellular response to hypoxia|
|regulation of synaptic plasticity|
|calcium ion transmembrane transport|
|cellular response to decreased oxygen levels|
|calmodulin binding|
|gliogenesis|
|cellular response to oxygen levels|
|regulation of muscle system process|
|regulation of heart contraction|
|calcium ion transport|
|telencephalon development|
|learning or memory|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|divalent metal ion transport|
|cognition|
|divalent inorganic cation transport|
|microtubule|
|regulation of cytosolic calcium ion concentration|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|forebrain development|
|monovalent inorganic cation transport|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|cellular response to organic cyclic compound|
|cell junction|
|cellular metal ion homeostasis|
|hemopoiesis|
|inorganic cation transmembrane transport|
|behavior|
|regulation of system process|
|cellular response to organonitrogen compound|
|hematopoietic or lymphoid organ development|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|immune system development|
|cellular response to nitrogen compound|
|import into cell|
|perinuclear region of cytoplasm|
|cation homeostasis|
|inorganic ion homeostasis|
|brain development|
|cellular chemical homeostasis|
|head development|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|central nervous system development|
|response to organonitrogen compound|
|export from cell|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|neurogenesis|
|homeostatic process|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.74|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12089
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC8A3 Expression in NALM6 Cells: -0.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>