SLC9A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC9A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC9A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 9 member A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6548|6548]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19634|P19634]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC9A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC9A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107310|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. {ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:8901634}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Na H Exchanger|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cation-transporting ATPase complex|
|sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential|
|regulation of the force of heart contraction by cardiac conduction|
|positive regulation of calcium:sodium antiporter activity|
|regulation of calcium:sodium antiporter activity|
|positive regulation of the force of heart contraction|
|regulation of cardiac muscle cell membrane potential|
|solute:proton antiporter activity|
|protein phosphatase 2B binding|
|cellular response to cold|
|positive regulation of action potential|
|potassium:proton antiporter activity|
|cellular response to electrical stimulus|
|sodium:proton antiporter activity|
|cellular response to acidic pH|
|cellular response to epinephrine stimulus|
|sodium ion export across plasma membrane|
|sodium ion import across plasma membrane|
|positive regulation of sodium ion transmembrane transporter activity|
|positive regulation of calcineurin-NFAT signaling cascade|
|positive regulation of calcineurin-mediated signaling|
|response to epinephrine|
|hyaluronan catabolic process|
|cellular sodium ion homeostasis|
|maintenance of cell polarity|
|response to muscle stretch|
|positive regulation of mitochondrial membrane permeability|
|positive regulation of sodium ion transmembrane transport|
|response to acidic pH|
|cellular response to pH|
|positive regulation of membrane permeability|
|regulation of cardiac muscle contraction by calcium ion signaling|
|regulation of the force of heart contraction|
|positive regulation of cardiac muscle hypertrophy|
|hyaluronan metabolic process|
|positive regulation of muscle hypertrophy|
|sodium ion homeostasis|
|regulation of calcineurin-mediated signaling|
|regulation of calcineurin-NFAT signaling cascade|
|positive regulation of sodium ion transport|
|positive regulation of calcium ion transmembrane transporter activity|
|export across plasma membrane|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|response to pH|
|cardiac muscle cell contraction|
|T-tubule|
|response to electrical stimulus|
|positive regulation of calcium-mediated signaling|
|intercalated disc|
|molecular adaptor activity|
|response to cold|
|regulation of action potential|
|neuron death|
|regulation of sodium ion transmembrane transporter activity|
|regulation of cardiac muscle hypertrophy|
|regulation of muscle hypertrophy|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|glycosaminoglycan catabolic process|
|calcium-dependent protein binding|
|regulation of sodium ion transmembrane transport|
|aminoglycan catabolic process|
|regulation of adherens junction organization|
|positive regulation of calcium ion transmembrane transport|
|regulation of mitochondrial membrane permeability|
|inorganic cation import across plasma membrane|
|inorganic ion import across plasma membrane|
|regulation of cardiac muscle contraction|
|phosphatidylinositol-4,5-bisphosphate binding|
|cardiac muscle contraction|
|regulation of stress fiber assembly|
|cellular response to mechanical stimulus|
|protein binding, bridging|
|regulation of membrane permeability|
|regulation of intracellular pH|
|regulation of muscle adaptation|
|heart contraction|
|regulation of sodium ion transport|
|cardiac muscle cell differentiation|
|regulation of calcium ion transmembrane transporter activity|
|regulation of cell junction assembly|
|actin-mediated cell contraction|
|regulation of actomyosin structure organization|
|sodium ion transmembrane transport|
|regulation of cellular pH|
|regulation of striated muscle contraction|
|cardiac conduction|
|regulation of actin filament bundle assembly|
|regulation of calcium-mediated signaling|
|import across plasma membrane|
|regulation of pH|
|heart process|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|positive regulation of ion transmembrane transporter activity|
|response to monoamine|
|response to catecholamine|
|mucopolysaccharide metabolic process|
|striated muscle contraction|
|cellular monovalent inorganic cation homeostasis|
|actin filament-based movement|
|positive regulation of transporter activity|
|regulation of cell-matrix adhesion|
|cardiocyte differentiation|
|cellular response to antibiotic|
|positive regulation of calcium ion transport|
|mitochondrial membrane organization|
|multicellular organismal signaling|
|regulation of nervous system process|
|monovalent inorganic cation homeostasis|
|positive regulation of cation transmembrane transport|
|proton transmembrane transport|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|sodium ion transport|
|positive regulation of ion transmembrane transport|
|glycosaminoglycan metabolic process|
|potassium ion transmembrane transport|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|cellular response to insulin stimulus|
|positive regulation of cell growth|
|aminoglycan metabolic process|
|potassium ion transport|
|response to temperature stimulus|
|lamellipodium|
|cellular response to hypoxia|
|carbohydrate derivative catabolic process|
|establishment or maintenance of cell polarity|
|basolateral plasma membrane|
|cellular response to decreased oxygen levels|
|striated muscle cell differentiation|
|calmodulin binding|
|positive regulation of transmembrane transport|
|regulation of cell-substrate adhesion|
|response to mechanical stimulus|
|mitochondrial transport|
|cellular response to oxygen levels|
|membrane raft|
|response to insulin|
|regulation of muscle system process|
|regulation of heart contraction|
|muscle cell differentiation|
|regulation of calcium ion transport|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|positive regulation of growth|
|regulation of actin filament organization|
|regulation of transmembrane transporter activity|
|carboxylic acid catabolic process|
|cellular response to peptide hormone stimulus|
|organic acid catabolic process|
|positive regulation of ion transport|
|anion transmembrane transport|
|regulation of transporter activity|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle tissue development|
|muscle system process|
|response to antibiotic|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|apical plasma membrane|
|cellular response to peptide|
|regulation of cation transmembrane transport|
|cellular response to external stimulus|
|second-messenger-mediated signaling|
|regulation of actin cytoskeleton organization|
|response to hypoxia|
|regulation of supramolecular fiber organization|
|response to decreased oxygen levels|
|response to oxygen levels|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|monovalent inorganic cation transport|
|focal adhesion|
|regulation of cell growth|
|regulation of membrane potential|
|small molecule catabolic process|
|mitochondrion organization|
|response to peptide|
|muscle structure development|
|regulation of ion transmembrane transport|
|protein complex oligomerization|
|heart development|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|actin filament-based process|
|anion transport|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|regulation of growth|
|import into cell|
|regulation of cell adhesion|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|membrane organization|
|circulatory system development|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|carboxylic acid metabolic process|
|response to hormone|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of transport|
|negative regulation of cell death|
|response to organonitrogen compound|
|oxoacid metabolic process|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|export from cell|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cell death|
|chemical homeostasis|
|response to abiotic stimulus|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|mitochondrion|
|transmembrane transport|
|regulation of organelle organization|
|locomotion|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.439|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13569
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC9A1 Expression in NALM6 Cells: 5.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>