SLC9A6 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC9A6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC9A6
  * **<color #00a2e8>Official Name</color>**: solute carrier family 9 member A6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10479|10479]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92581|Q92581]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC9A6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC9A6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300231|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic cognitive disability, Christianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Na H Exchanger|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|axonal spine|
|brain-derived neurotrophic factor receptor signaling pathway|
|dendrite extension|
|potassium:proton antiporter activity|
|sodium:proton antiporter activity|
|regulation of neurotrophin TRK receptor signaling pathway|
|sodium ion import across plasma membrane|
|dendritic spine development|
|axon extension|
|axon terminus|
|neuron projection extension|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|recycling endosome membrane|
|regulation of intracellular pH|
|developmental cell growth|
|sodium ion transmembrane transport|
|cell growth|
|regulation of cellular pH|
|import across plasma membrane|
|regulation of pH|
|dendrite development|
|cellular monovalent inorganic cation homeostasis|
|developmental growth involved in morphogenesis|
|recycling endosome|
|late endosome|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|early endosome membrane|
|sodium ion transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|synapse organization|
|regulation of cellular response to growth factor stimulus|
|anion transmembrane transport|
|axonogenesis|
|developmental growth|
|growth|
|monovalent inorganic cation transport|
|axon development|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|cell morphogenesis involved in differentiation|
|inorganic cation transmembrane transport|
|anion transport|
|cation transmembrane transport|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|neuron projection development|
|import into cell|
|intracellular membrane-bounded organelle|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cell morphogenesis|
|cellular chemical homeostasis|
|ion homeostasis|
|neuron development|
|cellular component morphogenesis|
|cation transport|
|cellular homeostasis|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|neuron differentiation|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|mitochondrion|
|transmembrane transport|
|ion transport|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14222
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC9A6 Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>