SLC9C1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC9C1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC9C1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 9 member C1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=285335|285335]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q4G0N8|Q4G0N8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC9C1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC9C1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612738|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Na H Exchanger|
|cNMP binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|potassium:proton antiporter activity|
|sodium:proton antiporter activity|
|sodium ion import across plasma membrane|
|ion channel activity|
|sperm motility|
|flagellated sperm motility|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|regulation of intracellular pH|
|sodium ion transmembrane transport|
|regulation of cellular pH|
|cilium-dependent cell motility|
|cilium or flagellum-dependent cell motility|
|import across plasma membrane|
|regulation of pH|
|motile cilium|
|cellular monovalent inorganic cation homeostasis|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|sodium ion transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|anion transmembrane transport|
|monovalent inorganic cation transport|
|spermatogenesis|
|inorganic cation transmembrane transport|
|male gamete generation|
|anion transport|
|cation transmembrane transport|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|import into cell|
|gamete generation|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|multicellular organismal reproductive process|
|cation transport|
|sexual reproduction|
|multicellular organism reproduction|
|cellular homeostasis|
|ion transmembrane transport|
|multi-organism reproductive process|
|cell motility|
|localization of cell|
|chemical homeostasis|
|transmembrane transport|
|locomotion|
|ion transport|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.72|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.77|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15289
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC9C1 Expression in NALM6 Cells: -1.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>