SLITRK6 [The Human Chemical-Genetic Interaction Map Project]

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======= SLITRK6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLITRK6
  * **<color #00a2e8>Official Name</color>**: SLIT and NTRK like family member 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84189|84189]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H5Y7|Q9H5Y7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLITRK6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLITRK6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609681|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness. [provided by RefSeq, Dec 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|linear vestibuloocular reflex|
|vestibular reflex|
|vestibulocochlear nerve development|
|auditory behavior|
|auditory receptor cell morphogenesis|
|mechanosensory behavior|
|auditory receptor cell development|
|reflex|
|response to auditory stimulus|
|inner ear auditory receptor cell differentiation|
|startle response|
|innervation|
|hair cell differentiation|
|inner ear receptor cell development|
|neuroepithelial cell differentiation|
|columnar/cuboidal epithelial cell development|
|cranial nerve development|
|cochlea development|
|inner ear receptor cell differentiation|
|mechanoreceptor differentiation|
|positive regulation of synapse assembly|
|adult locomotory behavior|
|lens development in camera-type eye|
|nerve development|
|multicellular organism growth|
|synapse assembly|
|columnar/cuboidal epithelial cell differentiation|
|inner ear morphogenesis|
|regulation of synapse assembly|
|neuromuscular process|
|ear morphogenesis|
|adult behavior|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|epithelial cell development|
|inner ear development|
|locomotory behavior|
|response to mechanical stimulus|
|regulation of synapse organization|
|ear development|
|visual perception|
|sensory perception of light stimulus|
|regulation of synapse structure or activity|
|sensory organ morphogenesis|
|synapse organization|
|embryonic organ morphogenesis|
|camera-type eye development|
|epidermal cell differentiation|
|eye development|
|visual system development|
|sensory system development|
|axonogenesis|
|developmental growth|
|growth|
|axon development|
|epidermis development|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|sensory organ development|
|cell morphogenesis involved in differentiation|
|embryonic morphogenesis|
|behavior|
|cell surface|
|neuron projection development|
|epithelial cell differentiation|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|regulation of nervous system development|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|sensory perception|
|embryo development|
|neuron differentiation|
|epithelium development|
|plasma membrane bounded cell projection organization|
|response to abiotic stimulus|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|nervous system process|
|integral component of plasma membrane|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.16|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5718
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLITRK6 Expression in NALM6 Cells: -3.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>