SLMAP [The Human Chemical-Genetic Interaction Map Project]

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======= SLMAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLMAP
  * **<color #00a2e8>Official Name</color>**: sarcolemma associated protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7871|7871]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14BN4|Q14BN4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLMAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLMAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602701|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FHA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of voltage-gated sodium channel activity|
|regulation of membrane depolarization during cardiac muscle cell action potential|
|regulation of membrane depolarization during action potential|
|smooth endoplasmic reticulum|
|regulation of cardiac muscle cell action potential|
|regulation of membrane depolarization|
|regulation of action potential|
|regulation of sodium ion transmembrane transporter activity|
|regulation of sodium ion transmembrane transport|
|regulation of sodium ion transport|
|sarcolemma|
|microtubule organizing center|
|regulation of cation channel activity|
|protein localization to plasma membrane|
|protein localization to cell periphery|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|muscle system process|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|regulation of transmembrane transport|
|regulation of ion transport|
|ion homeostasis|
|chemical homeostasis|
|integral component of plasma membrane|
|cellular protein localization|
|cellular macromolecule localization|
|homeostatic process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.9|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.89|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.78|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.79|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.92|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.39|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4654
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLMAP Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>