SLX1A [The Human Chemical-Genetic Interaction Map Project]

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======= SLX1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLX1A
  * **<color #00a2e8>Official Name</color>**: SLX1 homolog A, structure-specific endonuclease subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=548593|548593]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQ83|Q9BQ83]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLX1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLX1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615822|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. {ECO:0000255|HAMAP-Rule:MF_03100, ECO:0000269|PubMed:19595721, ECO:0000269|PubMed:19596235, ECO:0000269|PubMed:19596236}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GIY-YIG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Slx1-Slx4 complex|
|positive regulation of t-circle formation|
|DNA double-strand break processing involved in repair via single-strand annealing|
|double-strand break repair via single-strand annealing|
|5-flap endonuclease activity|
|telomeric D-loop disassembly|
|regulation of t-circle formation|
|crossover junction endodeoxyribonuclease activity|
|t-circle formation|
|telomere maintenance via telomere trimming|
|formation of extrachromosomal circular DNA|
|telomeric loop disassembly|
|DNA double-strand break processing|
|negative regulation of telomere maintenance via telomere lengthening|
|telomere maintenance via telomere lengthening|
|negative regulation of telomere maintenance|
|positive regulation of telomere maintenance|
|interstrand cross-link repair|
|regulation of telomere maintenance via telomere lengthening|
|non-recombinational repair|
|regulation of telomere maintenance|
|double-strand break repair via homologous recombination|
|recombinational repair|
|telomere maintenance|
|telomere organization|
|negative regulation of DNA metabolic process|
|negative regulation of chromosome organization|
|positive regulation of chromosome organization|
|double-strand break repair|
|positive regulation of DNA metabolic process|
|DNA recombination|
|nucleic acid phosphodiester bond hydrolysis|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|DNA repair|
|positive regulation of cellular component biogenesis|
|positive regulation of organelle organization|
|negative regulation of cellular component organization|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|regulation of cellular component biogenesis|
|chromosome organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|negative regulation of nucleobase-containing compound metabolic process|
|homeostatic process|
|cellular response to stress|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5955
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLX1A Expression in NALM6 Cells: 3.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>