SMARCC1 [The Human Chemical-Genetic Interaction Map Project]

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======= SMARCC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMARCC1
  * **<color #00a2e8>Official Name</color>**: SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6599|6599]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92922|Q92922]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMARCC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMARCC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601732|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex (PubMed:10078207). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250|UniProtKB:P97496, ECO:0000269|PubMed:10078207, ECO:0000269|PubMed:11018012, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SWIRM|
|Myb DNA-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|npBAF complex|
|XY body|
|nBAF complex|
|nucleosome disassembly|
|chromatin disassembly|
|SWI/SNF complex|
|protein-DNA complex disassembly|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|prostate gland development|
|nucleosomal DNA binding|
|negative regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of proteasomal protein catabolic process|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|ATP-dependent chromatin remodeling|
|negative regulation of cellular protein catabolic process|
|insulin receptor signaling pathway|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|protein N-terminus binding|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|histone binding|
|negative regulation of protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|cellular response to insulin stimulus|
|regulation of proteasomal protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|response to insulin|
|nuclear chromatin|
|protein-containing complex disassembly|
|protein-DNA complex subunit organization|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|cellular response to peptide hormone stimulus|
|transcription coactivator activity|
|negative regulation of catabolic process|
|urogenital system development|
|cellular response to peptide|
|negative regulation of proteolysis|
|regulation of protein catabolic process|
|response to peptide hormone|
|cellular component disassembly|
|gland development|
|reproductive structure development|
|reproductive system development|
|response to peptide|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|protein-containing complex|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|chromatin organization|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|regulation of cellular catabolic process|
|response to hormone|
|animal organ morphogenesis|
|regulation of catabolic process|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|chromosome organization|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.09|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.9|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.87|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.72|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.74|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.76|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.77|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.79|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.79|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.83|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.09|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.15|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|2.31|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|2.32|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2.59|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.74|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.99|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:arid1a|ARID1A]]|0.489|
|[[:human genes:s:smarcb1|SMARCB1]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1868
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMARCC1 Expression in NALM6 Cells: 8.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>