SMC4 [The Human Chemical-Genetic Interaction Map Project]

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======= SMC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMC4
  * **<color #00a2e8>Official Name</color>**: structural maintenance of chromosomes 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10051|10051]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NTJ3|Q9NTJ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605575|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SMC hinge|
|SMC N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|meiotic chromosome condensation|
|condensin complex|
|mitotic chromosome condensation|
|kinetochore organization|
|chromosome condensation|
|chromosome organization involved in meiotic cell cycle|
|meiotic chromosome segregation|
|single-stranded DNA binding|
|mitotic sister chromatid segregation|
|sister chromatid segregation|
|mitotic nuclear division|
|meiotic nuclear division|
|meiotic cell cycle process|
|DNA packaging|
|nuclear chromosome segregation|
|meiotic cell cycle|
|chromosome segregation|
|nuclear division|
|DNA conformation change|
|organelle fission|
|nuclear speck|
|protein heterodimerization activity|
|cell division|
|mitotic cell cycle process|
|mitotic cell cycle|
|cell cycle process|
|chromosome organization|
|cell cycle|
|reproductive process|
|reproduction|
|ATP binding|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.22|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.9|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.85|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.71|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.08|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.45|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.451|
|[[:human genes:r:rps11|RPS11]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 627/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|28/28|
|bone|24/25|
|breast|30/33|
|central nervous system|46/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|11/15|
|kidney|20/21|
|liver|19/20|
|lung|66/75|
|lymphocyte|12/14|
|ovary|18/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|7/7|
|thyroid|1/2|
|upper aerodigestive|18/22|
|urinary tract|23/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1718
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMC4 Expression in NALM6 Cells: 9.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>