SMC5 [The Human Chemical-Genetic Interaction Map Project]

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======= SMC5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMC5
  * **<color #00a2e8>Official Name</color>**: structural maintenance of chromosomes 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23137|23137]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IY18|Q8IY18]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMC5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMC5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609386|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). {ECO:0000269|PubMed:16810316, ECO:0000269|PubMed:17589526, ECO:0000269|PubMed:19502785, ECO:0000269|PubMed:26983541}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SMC N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sex chromosome|
|positive regulation of maintenance of sister chromatid cohesion|
|positive regulation of maintenance of mitotic sister chromatid cohesion|
|interchromatin granule|
|Smc5-Smc6 complex|
|regulation of maintenance of mitotic sister chromatid cohesion|
|regulation of maintenance of sister chromatid cohesion|
|positive regulation of sister chromatid cohesion|
|telomere maintenance via recombination|
|positive regulation of mitotic sister chromatid segregation|
|mitotic recombination|
|regulation of sister chromatid cohesion|
|positive regulation of chromosome segregation|
|cellular senescence|
|sister chromatid cohesion|
|chromosome, telomeric region|
|positive regulation of mitotic nuclear division|
|site of double-strand break|
|double-strand break repair via nonhomologous end joining|
|non-recombinational repair|
|cell aging|
|positive regulation of nuclear division|
|regulation of mitotic sister chromatid segregation|
|regulation of sister chromatid segregation|
|double-strand break repair via homologous recombination|
|recombinational repair|
|telomere maintenance|
|PML body|
|telomere organization|
|regulation of chromosome segregation|
|sister chromatid segregation|
|positive regulation of mitotic cell cycle|
|regulation of mitotic nuclear division|
|positive regulation of chromosome organization|
|double-strand break repair|
|regulation of nuclear division|
|nuclear chromosome segregation|
|DNA recombination|
|chromosome segregation|
|aging|
|positive regulation of cell cycle process|
|anatomical structure homeostasis|
|regulation of chromosome organization|
|positive regulation of cell cycle|
|nuclear speck|
|cell division|
|DNA repair|
|cell junction|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|ATP binding|
|homeostatic process|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.58|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.24|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.9|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.76|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|3.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:smc6|SMC6]]|0.47|
|[[:human genes:n:nsmce1|NSMCE1]]|0.424|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 44/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|3/28|
|bone|4/25|
|breast|2/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|1/21|
|liver|3/20|
|lung|3/75|
|lymphocyte|1/14|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 465
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMC5 Expression in NALM6 Cells: 7.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>