SMG8 [The Human Chemical-Genetic Interaction Map Project]

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======= SMG8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMG8
  * **<color #00a2e8>Official Name</color>**: SMG8 nonsense mediated mRNA decay factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55181|55181]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8ND04|Q8ND04]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMG8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMG8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613175|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. {ECO:0000269|PubMed:19417104}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2146|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|cellular component|
|organic cyclic compound catabolic process|
|mRNA metabolic process|
|regulation of protein kinase activity|
|regulation of kinase activity|
|cellular macromolecule catabolic process|
|regulation of transferase activity|
|macromolecule catabolic process|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.61|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.18|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.18|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-2.14|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.1|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.96|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.96|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.96|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.91|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.86|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.85|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.84|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.83|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.78|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.78|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.74|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:smg9|SMG9]]|0.494|
|[[:human genes:h:hars|HARS]]|0.42|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3161
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMG8 Expression in NALM6 Cells: 5.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>