SMTN [The Human Chemical-Genetic Interaction Map Project]

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======= SMTN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMTN
  * **<color #00a2e8>Official Name</color>**: smoothelin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6525|6525]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53814|P53814]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMTN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMTN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602127|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAMSAP CH|
|Smoothelin|
|CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|filamentous actin|
|structural constituent of muscle|
|smooth muscle contraction|
|microtubule organizing center|
|actin cytoskeleton|
|muscle contraction|
|actin binding|
|muscle organ development|
|muscle system process|
|cytoskeleton|
|muscle structure development|
|actin cytoskeleton organization|
|actin filament-based process|
|cytoskeleton organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.75|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.715|
|[[:human genes:p:polr2j3|POLR2J3]]|0.546|
|[[:human genes:n:narfl|NARFL]]|0.514|
|[[:human genes:p:psmb4|PSMB4]]|0.502|
|[[:human genes:c:chd4|CHD4]]|0.488|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.467|
|[[:human genes:t:tceb3c|TCEB3C]]|0.456|
|[[:human genes:e:egr2|EGR2]]|0.448|
|[[:human genes:s:slc4a1|SLC4A1]]|0.446|
|[[:human genes:s:slc6a17|SLC6A17]]|0.444|
|[[:human genes:a:aatf|AATF]]|0.441|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.431|
|[[:human genes:t:tyms|TYMS]]|0.431|
|[[:human genes:a:akt1s1|AKT1S1]]|0.43|
|[[:human genes:t:tspy8|TSPY8]]|0.428|
|[[:human genes:n:nupl1|NUPL1]]|0.427|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.423|
|[[:human genes:c:cactin|CACTIN]]|0.421|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.417|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.417|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.417|
|[[:human genes:u:utp3|UTP3]]|0.414|
|[[:human genes:e:exosc5|EXOSC5]]|0.411|
|[[:human genes:c:copg1|COPG1]]|0.41|
|[[:human genes:p:prpf19|PRPF19]]|0.409|
|[[:human genes:c:cdt1|CDT1]]|0.409|
|[[:human genes:k:kctd17|KCTD17]]|0.406|
|[[:human genes:r:rbm39|RBM39]]|0.404|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.403|
|[[:human genes:s:snip1|SNIP1]]|0.403|
|[[:human genes:i:ints5|INTS5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2276
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMTN Expression in NALM6 Cells: 4.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>