SMURF2 [The Human Chemical-Genetic Interaction Map Project]

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======= SMURF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMURF2
  * **<color #00a2e8>Official Name</color>**: SMAD specific E3 ubiquitin protein ligase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64750|64750]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HAU4|Q9HAU4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMURF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMURF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605532|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. {ECO:0000269|PubMed:11389444, ECO:0000269|PubMed:12717440}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
|WW|
|HECT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-dependent SMAD protein catabolic process|
|positive regulation of trophoblast cell migration|
|regulation of trophoblast cell migration|
|transforming growth factor beta receptor binding|
|negative regulation of BMP signaling pathway|
|SMAD binding|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|positive regulation of reproductive process|
|regulation of BMP signaling pathway|
|BMP signaling pathway|
|Wnt signaling pathway, planar cell polarity pathway|
|cellular response to BMP stimulus|
|response to BMP|
|ubiquitin ligase complex|
|regulation of establishment of planar polarity|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|non-canonical Wnt signaling pathway|
|positive regulation of canonical Wnt signaling pathway|
|negative regulation of cellular response to growth factor stimulus|
|regulation of reproductive process|
|positive regulation of Wnt signaling pathway|
|regulation of morphogenesis of an epithelium|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|positive regulation of protein catabolic process|
|ubiquitin protein ligase activity|
|membrane raft|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|ubiquitin-protein transferase activity|
|regulation of animal organ morphogenesis|
|regulation of cellular response to growth factor stimulus|
|protein deubiquitination|
|regulation of canonical Wnt signaling pathway|
|protein modification by small protein removal|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|regulation of protein catabolic process|
|nuclear speck|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|positive regulation of cell motility|
|ubiquitin-dependent protein catabolic process|
|response to growth factor|
|modification-dependent protein catabolic process|
|positive regulation of cellular component movement|
|modification-dependent macromolecule catabolic process|
|positive regulation of locomotion|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|enzyme linked receptor protein signaling pathway|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|cellular macromolecule catabolic process|
|regulation of cell motility|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|regulation of cellular component movement|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|identical protein binding|
|cell-cell signaling|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.76|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.73|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.77|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17230
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMURF2 Expression in NALM6 Cells: 4.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>