SMYD3 [The Human Chemical-Genetic Interaction Map Project]

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======= SMYD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMYD3
  * **<color #00a2e8>Official Name</color>**: SET and MYND domain containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64754|64754]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H7B4|Q9H7B4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMYD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMYD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608783|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Histone methyltransferase. Specifically methylates 'Lys- 4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'- CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609). {ECO:0000269|PubMed:15235609, ECO:0000269|PubMed:22419068}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SET|
|zf-MYND|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|
|histone-lysine N-methyltransferase activity|
|myotube cell development|
|cellular response to dexamethasone stimulus|
|RNA polymerase II complex binding|
|response to dexamethasone|
|cellular response to glucocorticoid stimulus|
|myotube differentiation|
|cellular response to corticosteroid stimulus|
|histone lysine methylation|
|peptidyl-lysine methylation|
|cellular response to ketone|
|histone methylation|
|response to antineoplastic agent|
|positive regulation of peptidyl-serine phosphorylation|
|nucleosome assembly|
|protein alkylation|
|protein methylation|
|chromatin assembly|
|striated muscle cell development|
|regulation of peptidyl-serine phosphorylation|
|response to glucocorticoid|
|muscle cell development|
|chromatin assembly or disassembly|
|nucleosome organization|
|response to corticosteroid|
|DNA packaging|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|response to ketone|
|striated muscle cell differentiation|
|protein-DNA complex assembly|
|negative regulation of protein kinase activity|
|protein-DNA complex subunit organization|
|muscle cell differentiation|
|negative regulation of kinase activity|
|macromolecule methylation|
|negative regulation of transferase activity|
|DNA conformation change|
|response to xenobiotic stimulus|
|methylation|
|peptidyl-lysine modification|
|response to steroid hormone|
|histone modification|
|covalent chromatin modification|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|muscle structure development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|chromatin organization|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|cellular protein-containing complex assembly|
|response to lipid|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|response to hormone|
|response to organic cyclic compound|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|chromosome organization|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6751
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMYD3 Expression in NALM6 Cells: 3.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>