SNAP25 [The Human Chemical-Genetic Interaction Map Project]

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======= SNAP25 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNAP25
  * **<color #00a2e8>Official Name</color>**: synaptosome associated protein 25
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6616|6616]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60880|P60880]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNAP25&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNAP25|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600322|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SNARE|
|SNAP-25|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|
|exocytic insertion of neurotransmitter receptor to postsynaptic membrane|
|synaptic vesicle docking|
|somatodendritic compartment|
|synaptic vesicle fusion to presynaptic active zone membrane|
|neurotransmitter receptor internalization|
|vesicle fusion to plasma membrane|
|synaptic vesicle priming|
|neurotransmitter receptor transport to plasma membrane|
|BLOC-1 complex|
|neurotransmitter receptor transport to postsynaptic membrane|
|establishment of protein localization to postsynaptic membrane|
|syntaxin-1 binding|
|neurotransmitter uptake|
|glutamate secretion|
|SNAP receptor activity|
|protein localization to postsynaptic membrane|
|neurotransmitter receptor transport|
|vesicle docking involved in exocytosis|
|receptor localization to synapse|
|long-term synaptic potentiation|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|acidic amino acid transport|
|SNARE complex|
|syntaxin binding|
|voltage-gated potassium channel activity|
|extrinsic component of cytoplasmic side of plasma membrane|
|calcium-dependent protein binding|
|receptor internalization|
|vesicle docking|
|protein localization to synapse|
|synaptic vesicle exocytosis|
|exocytic process|
|vesicle fusion|
|tertiary granule membrane|
|presynaptic membrane|
|organelle membrane fusion|
|associative learning|
|dicarboxylic acid transport|
|acid secretion|
|postsynapse|
|voltage-gated potassium channel complex|
|specific granule membrane|
|vesicle-mediated transport to the plasma membrane|
|organelle fusion|
|signal release from synapse|
|neurotransmitter secretion|
|receptor metabolic process|
|amino acid transport|
|synaptic vesicle cycle|
|synaptic vesicle|
|growth cone|
|vesicle-mediated transport in synapse|
|membrane fusion|
|vesicle|
|learning|
|positive regulation of synaptic transmission|
|potassium ion transmembrane transport|
|potassium ion transport|
|signal release|
|trans-Golgi network|
|organelle localization by membrane tethering|
|regulation of insulin secretion|
|membrane docking|
|neurotransmitter transport|
|regulation of synaptic plasticity|
|locomotory behavior|
|regulation of peptide hormone secretion|
|protein localization to cell periphery|
|receptor-mediated endocytosis|
|protein-containing complex localization|
|learning or memory|
|establishment of protein localization to membrane|
|regulation of hormone secretion|
|organic acid transport|
|carboxylic acid transport|
|cognition|
|vesicle organization|
|neuron projection|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|cytoskeleton|
|monovalent inorganic cation transport|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|establishment of protein localization to organelle|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|regulation of protein secretion|
|protein localization to membrane|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of peptide secretion|
|regulation of neuron projection development|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of hormone levels|
|cell junction|
|endocytosis|
|inorganic cation transmembrane transport|
|behavior|
|organelle localization|
|anion transport|
|myeloid leukocyte activation|
|cation transmembrane transport|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of neuron differentiation|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|regulation of protein transport|
|regulation of cell projection organization|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|leukocyte mediated immunity|
|exocytosis|
|regulation of secretion|
|regulation of neurogenesis|
|cation transport|
|cellular protein-containing complex assembly|
|membrane organization|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|ion transmembrane transport|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cell activation|
|immune effector process|
|cell-cell signaling|
|secretion|
|transmembrane transport|
|ion transport|
|nervous system process|
|protein transport|
|generation of neurons|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.78|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15698
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNAP25 Expression in NALM6 Cells: -3.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>