SNAPC5 [The Human Chemical-Genetic Interaction Map Project]

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======= SNAPC5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNAPC5
  * **<color #00a2e8>Official Name</color>**: small nuclear RNA activating complex polypeptide 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10302|10302]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75971|O75971]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNAPC5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNAPC5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605979|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits other regulatory factors to activate snRNA gene transcription. The encoded protein may play a role in stabilizing this complex. A pseudogene of this gene has been identified on chromosome 6. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription initiation from RNA polymerase III promoter|
|transcription by RNA polymerase III|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|DNA-templated transcription, initiation|
|nuclear body|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|nucleolus|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-3.06|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.87|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.38|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-2.21|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-2.17|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-2.09|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.08|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2.04|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.85|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.84|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.78|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.72|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.72|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.75|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.79|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.93|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gemin8|GEMIN8]]|0.581|
|[[:human genes:g:gnb1l|GNB1L]]|0.52|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.517|
|[[:human genes:t:thg1l|THG1L]]|0.508|
|[[:human genes:g:gemin6|GEMIN6]]|0.494|
|[[:human genes:s:srp14|SRP14]]|0.491|
|[[:human genes:d:ddx20|DDX20]]|0.49|
|[[:human genes:p:ppp4c|PPP4C]]|0.483|
|[[:human genes:r:rpp21|RPP21]]|0.48|
|[[:human genes:r:rabggtb|RABGGTB]]|0.474|
|[[:human genes:r:rnmt|RNMT]]|0.466|
|[[:human genes:g:gemin7|GEMIN7]]|0.465|
|[[:human genes:o:osgep|OSGEP]]|0.464|
|[[:human genes:t:tti1|TTI1]]|0.462|
|[[:human genes:r:rtcb|RTCB]]|0.462|
|[[:human genes:m:med16|MED16]]|0.462|
|[[:human genes:p:pmm2|PMM2]]|0.461|
|[[:human genes:n:n6amt1|N6AMT1]]|0.46|
|[[:human genes:w:wdr92|WDR92]]|0.459|
|[[:human genes:u:uhrf1|UHRF1]]|0.456|
|[[:human genes:a:alg1|ALG1]]|0.452|
|[[:human genes:g:gemin5|GEMIN5]]|0.447|
|[[:human genes:b:bub3|BUB3]]|0.444|
|[[:human genes:e:exoc4|EXOC4]]|0.443|
|[[:human genes:c:c15orf41|C15orf41]]|0.442|
|[[:human genes:t:tut1|TUT1]]|0.437|
|[[:human genes:s:snf8|SNF8]]|0.437|
|[[:human genes:d:dr1|DR1]]|0.437|
|[[:human genes:d:dctn6|DCTN6]]|0.436|
|[[:human genes:t:tti2|TTI2]]|0.435|
|[[:human genes:g:gemin4|GEMIN4]]|0.435|
|[[:human genes:d:dpagt1|DPAGT1]]|0.432|
|[[:human genes:z:zrsr2|ZRSR2]]|0.431|
|[[:human genes:g:gmppb|GMPPB]]|0.429|
|[[:human genes:d:ddx1|DDX1]]|0.425|
|[[:human genes:u:uap1|UAP1]]|0.425|
|[[:human genes:w:wdr77|WDR77]]|0.424|
|[[:human genes:t:tbcb|TBCB]]|0.424|
|[[:human genes:v:vezt|VEZT]]|0.424|
|[[:human genes:c:cep57|CEP57]]|0.423|
|[[:human genes:p:polr3h|POLR3H]]|0.422|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.421|
|[[:human genes:u:uxt|UXT]]|0.42|
|[[:human genes:t:telo2|TELO2]]|0.417|
|[[:human genes:t:tsen54|TSEN54]]|0.417|
|[[:human genes:p:ppp6c|PPP6C]]|0.415|
|[[:human genes:d:dohh|DOHH]]|0.415|
|[[:human genes:p:pik3r4|PIK3R4]]|0.414|
|[[:human genes:t:taf1a|TAF1A]]|0.414|
|[[:human genes:a:alg13|ALG13]]|0.413|
|[[:human genes:e:exoc3|EXOC3]]|0.411|
|[[:human genes:a:atxn10|ATXN10]]|0.41|
|[[:human genes:a:adsl|ADSL]]|0.41|
|[[:human genes:t:tubd1|TUBD1]]|0.409|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.409|
|[[:human genes:a:alg2|ALG2]]|0.408|
|[[:human genes:z:znhit1|ZNHIT1]]|0.407|
|[[:human genes:g:gpn2|GPN2]]|0.406|
|[[:human genes:t:ten1|TEN1]]|0.405|
|[[:human genes:e:elp2|ELP2]]|0.405|
|[[:human genes:t:tprkb|TPRKB]]|0.405|
|[[:human genes:n:ncdn|NCDN]]|0.405|
|[[:human genes:p:ppcs|PPCS]]|0.402|
|[[:human genes:f:fh|FH]]|0.401|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.4|
|[[:human genes:l:lsm11|LSM11]]|0.4|
|[[:human genes:e:eprs|EPRS]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 728/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|31/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 947
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNAPC5 Expression in NALM6 Cells: 3.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>