SNAPIN [The Human Chemical-Genetic Interaction Map Project]

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======= SNAPIN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNAPIN
  * **<color #00a2e8>Official Name</color>**: SNAP associated protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23557|23557]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95295|O95295]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNAPIN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNAPIN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607007|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma- membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:18167355, ECO:0000269|PubMed:25898167}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of late endosome to lysosome transport|
|positive regulation of vacuolar transport|
|terminal button organization|
|late endosome to lysosome transport|
|regulation of late endosome to lysosome transport|
|regulation of vacuolar transport|
|lysosomal lumen acidification|
|BORC complex|
|synaptic vesicle maturation|
|regulation of lysosomal lumen pH|
|synaptic vesicle fusion to presynaptic active zone membrane|
|vesicle fusion to plasma membrane|
|synaptic vesicle cytoskeletal transport|
|anterograde synaptic vesicle transport|
|synaptic vesicle transport along microtubule|
|BLOC-1 complex|
|retrograde axonal transport|
|vacuolar acidification|
|presynapse organization|
|melanosome organization|
|cellular protein-containing complex localization|
|pigment granule organization|
|autophagosome maturation|
|synaptic vesicle transport|
|synaptic vesicle localization|
|vesicle transport along microtubule|
|anterograde axonal transport|
|lysosome localization|
|intracellular pH reduction|
|cellular pigmentation|
|pH reduction|
|vesicle cytoskeletal trafficking|
|endosome to lysosome transport|
|axonal transport|
|axon cytoplasm|
|lysosome organization|
|lytic vacuole organization|
|synaptic vesicle exocytosis|
|SNARE binding|
|axo-dendritic transport|
|exocytic process|
|synaptic vesicle membrane|
|vesicle fusion|
|organelle membrane fusion|
|regulation of synaptic vesicle exocytosis|
|organelle transport along microtubule|
|regulation of intracellular pH|
|secretory granule|
|regulation of cellular pH|
|pigmentation|
|organelle fusion|
|regulation of pH|
|signal release from synapse|
|neurotransmitter secretion|
|regulation of neurotransmitter secretion|
|lysosomal transport|
|cellular monovalent inorganic cation homeostasis|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|synaptic vesicle|
|vacuole organization|
|vesicle-mediated transport in synapse|
|membrane fusion|
|monovalent inorganic cation homeostasis|
|vacuolar transport|
|regulation of neurotransmitter transport|
|negative regulation of neuron projection development|
|transport along microtubule|
|macroautophagy|
|regulation of regulated secretory pathway|
|signal release|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|neurotransmitter transport|
|negative regulation of cell projection organization|
|microtubule-based transport|
|vesicle localization|
|regulation of protein binding|
|regulation of exocytosis|
|protein maturation|
|negative regulation of neuron differentiation|
|protein-containing complex disassembly|
|developmental maturation|
|protein-containing complex localization|
|autophagy|
|process utilizing autophagic mechanism|
|synapse|
|synapse organization|
|microtubule-based movement|
|negative regulation of neurogenesis|
|vesicle organization|
|lysosomal membrane|
|negative regulation of nervous system development|
|negative regulation of cell development|
|regulation of neurotransmitter levels|
|establishment of organelle localization|
|regulation of binding|
|cellular component disassembly|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|regulation of neuron projection development|
|cell junction|
|regulation of vesicle-mediated transport|
|organelle localization|
|Golgi membrane|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of neuron differentiation|
|neuron projection development|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|viral process|
|regulated exocytosis|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|symbiotic process|
|ion homeostasis|
|exocytosis|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|membrane organization|
|cellular homeostasis|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of transport|
|intracellular protein transport|
|secretion by cell|
|neuron differentiation|
|export from cell|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|homeostatic process|
|cell development|
|cellular catabolic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.92|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-2.52|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.88|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.71|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.88|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11088
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNAPIN Expression in NALM6 Cells: 4.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>