SNRNP35 [The Human Chemical-Genetic Interaction Map Project]

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======= SNRNP35 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNRNP35
  * **<color #00a2e8>Official Name</color>**: small nuclear ribonucleoprotein U11/U12 subunit 35
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11066|11066]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16560|Q16560]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNRNP35&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNRNP35|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619631|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U12-type spliceosomal complex|
|mRNA binding|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.12|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.02|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.91|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.85|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.74|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.462|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 608/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|25/28|
|bone|24/26|
|breast|30/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|16/21|
|liver|14/20|
|lung|61/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|16/24|
|peripheral nervous system|15/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|19/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 953
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNRNP35 Expression in NALM6 Cells: 4.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>