SNRPA1 [The Human Chemical-Genetic Interaction Map Project]

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======= SNRPA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNRPA1
  * **<color #00a2e8>Official Name</color>**: small nuclear ribonucleoprotein polypeptide A'
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6627|6627]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09661|P09661]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNRPA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNRPA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603521|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2 snRNA binding|
|small nuclear ribonucleoprotein complex|
|U2 snRNP|
|U2-type catalytic step 2 spliceosome|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|response to interleukin-12|
|U2-type precatalytic spliceosome|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|nuclear body|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|spermatogenesis|
|male gamete generation|
|cytokine-mediated signaling pathway|
|gamete generation|
|mRNA metabolic process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|RNA processing|
|multi-organism reproductive process|
|cellular response to cytokine stimulus|
|response to cytokine|
|RNA binding|
|reproductive process|
|reproduction|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.552|
|[[:human genes:m:mt1e|MT1E]]|0.544|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.536|
|[[:human genes:s:supt5h|SUPT5H]]|0.534|
|[[:human genes:t:tceb3c|TCEB3C]]|0.525|
|[[:human genes:o:orc6|ORC6]]|0.522|
|[[:human genes:c:cdc6|CDC6]]|0.522|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.521|
|[[:human genes:c:c14orf93|C14orf93]]|0.519|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.517|
|[[:human genes:n:ndc1|NDC1]]|0.517|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.512|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.511|
|[[:human genes:r:rrn3|RRN3]]|0.507|
|[[:human genes:x:xylt2|XYLT2]]|0.506|
|[[:human genes:c:cbwd3|CBWD3]]|0.505|
|[[:human genes:p:polr2j3|POLR2J3]]|0.504|
|[[:human genes:a:aqr|AQR]]|0.503|
|[[:human genes:n:npipb5|NPIPB5]]|0.503|
|[[:human genes:c:chaf1a|CHAF1A]]|0.502|
|[[:human genes:r:rad51|RAD51]]|0.501|
|[[:human genes:v:vasn|VASN]]|0.5|
|[[:human genes:a:acsf2|ACSF2]]|0.498|
|[[:human genes:d:dtl|DTL]]|0.498|
|[[:human genes:p:psmd1|PSMD1]]|0.497|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.496|
|[[:human genes:t:tfip11|TFIP11]]|0.496|
|[[:human genes:u:upf1|UPF1]]|0.495|
|[[:human genes:c:cdc73|CDC73]]|0.494|
|[[:human genes:e:eif4a3|EIF4A3]]|0.493|
|[[:human genes:z:znf655|ZNF655]]|0.493|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.491|
|[[:human genes:c:cbwd6|CBWD6]]|0.49|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.489|
|[[:human genes:c:ccna2|CCNA2]]|0.484|
|[[:human genes:r:rps9|RPS9]]|0.484|
|[[:human genes:a:ahctf1|AHCTF1]]|0.484|
|[[:human genes:c:cbwd5|CBWD5]]|0.483|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.481|
|[[:human genes:r:rrp15|RRP15]]|0.48|
|[[:human genes:c:copg1|COPG1]]|0.479|
|[[:human genes:r:rpl35|RPL35]]|0.478|
|[[:human genes:c:cwc22|CWC22]]|0.477|
|[[:human genes:n:narfl|NARFL]]|0.476|
|[[:human genes:n:nupl1|NUPL1]]|0.474|
|[[:human genes:c:cope|COPE]]|0.474|
|[[:human genes:c:chd4|CHD4]]|0.473|
|[[:human genes:r:rad21|RAD21]]|0.473|
|[[:human genes:s:stil|STIL]]|0.472|
|[[:human genes:n:nup160|NUP160]]|0.472|
|[[:human genes:m:myo1h|MYO1H]]|0.469|
|[[:human genes:s:sec13|SEC13]]|0.468|
|[[:human genes:c:cdca3|CDCA3]]|0.467|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.467|
|[[:human genes:p:psmc1|PSMC1]]|0.467|
|[[:human genes:s:ssh2|SSH2]]|0.466|
|[[:human genes:i:iscu|ISCU]]|0.465|
|[[:human genes:p:pole|POLE]]|0.463|
|[[:human genes:p:psmc6|PSMC6]]|0.462|
|[[:human genes:e:exosc5|EXOSC5]]|0.461|
|[[:human genes:p:psmd6|PSMD6]]|0.461|
|[[:human genes:p:psma6|PSMA6]]|0.46|
|[[:human genes:r:rps2|RPS2]]|0.459|
|[[:human genes:n:npipb3|NPIPB3]]|0.457|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.456|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.456|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.456|
|[[:human genes:s:s1pr4|S1PR4]]|0.455|
|[[:human genes:g:golga8o|GOLGA8O]]|0.454|
|[[:human genes:i:ints5|INTS5]]|0.454|
|[[:human genes:p:psmb2|PSMB2]]|0.453|
|[[:human genes:p:paf1|PAF1]]|0.453|
|[[:human genes:c:copb1|COPB1]]|0.451|
|[[:human genes:d:disp2|DISP2]]|0.451|
|[[:human genes:a:aaas|AAAS]]|0.449|
|[[:human genes:p:prim1|PRIM1]]|0.449|
|[[:human genes:u:ube2q2l|UBE2Q2L]]|0.448|
|[[:human genes:s:slc4a1|SLC4A1]]|0.448|
|[[:human genes:d:ddtl|DDTL]]|0.448|
|[[:human genes:t:ticrr|TICRR]]|0.446|
|[[:human genes:p:psmd3|PSMD3]]|0.446|
|[[:human genes:u:utp3|UTP3]]|0.445|
|[[:human genes:n:nufip2|NUFIP2]]|0.445|
|[[:human genes:s:supt6h|SUPT6H]]|0.445|
|[[:human genes:a:aamp|AAMP]]|0.445|
|[[:human genes:a:atp13a1|ATP13A1]]|0.444|
|[[:human genes:t:tuba8|TUBA8]]|0.444|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.444|
|[[:human genes:i:igfn1|IGFN1]]|0.444|
|[[:human genes:r:rps12|RPS12]]|0.444|
|[[:human genes:z:znf106|ZNF106]]|0.444|
|[[:human genes:c:ckap5|CKAP5]]|0.443|
|[[:human genes:p:psmd2|PSMD2]]|0.443|
|[[:human genes:w:wdr87|WDR87]]|0.441|
|[[:human genes:s:sf3a1|SF3A1]]|0.44|
|[[:human genes:r:rpsa|RPSA]]|0.439|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.439|
|[[:human genes:p:pan3|PAN3]]|0.438|
|[[:human genes:l:lad1|LAD1]]|0.437|
|[[:human genes:s:sap30bp|SAP30BP]]|0.436|
|[[:human genes:g:golga8j|GOLGA8J]]|0.436|
|[[:human genes:h:hap1|HAP1]]|0.436|
|[[:human genes:o:orc1|ORC1]]|0.436|
|[[:human genes:o:ogfr|OGFR]]|0.436|
|[[:human genes:p:psmd11|PSMD11]]|0.435|
|[[:human genes:c:cox8a|COX8A]]|0.433|
|[[:human genes:c:ccdc94|CCDC94]]|0.433|
|[[:human genes:p:pola2|POLA2]]|0.432|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.432|
|[[:human genes:w:wdr43|WDR43]]|0.432|
|[[:human genes:r:rps28|RPS28]]|0.432|
|[[:human genes:p:psmc2|PSMC2]]|0.431|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.43|
|[[:human genes:p:prmt8|PRMT8]]|0.43|
|[[:human genes:n:nup54|NUP54]]|0.429|
|[[:human genes:p:psmc5|PSMC5]]|0.429|
|[[:human genes:c:cactin|CACTIN]]|0.429|
|[[:human genes:r:rbm39|RBM39]]|0.428|
|[[:human genes:g:golga8h|GOLGA8H]]|0.428|
|[[:human genes:t:trim52|TRIM52]]|0.428|
|[[:human genes:e:exosc3|EXOSC3]]|0.428|
|[[:human genes:p:psma7|PSMA7]]|0.428|
|[[:human genes:m:msh5|MSH5]]|0.426|
|[[:human genes:i:ik|IK]]|0.426|
|[[:human genes:u:urb2|URB2]]|0.426|
|[[:human genes:r:rrp7a|RRP7A]]|0.426|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.426|
|[[:human genes:r:rpl34|RPL34]]|0.425|
|[[:human genes:n:napa|NAPA]]|0.424|
|[[:human genes:p:ppfia4|PPFIA4]]|0.424|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.423|
|[[:human genes:m:med17|MED17]]|0.423|
|[[:human genes:p:polr2f|POLR2F]]|0.422|
|[[:human genes:n:nup133|NUP133]]|0.421|
|[[:human genes:z:znf574|ZNF574]]|0.42|
|[[:human genes:f:fam160a1|FAM160A1]]|0.42|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.42|
|[[:human genes:p:pwp2|PWP2]]|0.42|
|[[:human genes:p:pan2|PAN2]]|0.419|
|[[:human genes:r:rbbp5|RBBP5]]|0.419|
|[[:human genes:f:fcn2|FCN2]]|0.419|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.419|
|[[:human genes:f:fbxw9|FBXW9]]|0.418|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.418|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.418|
|[[:human genes:s:sf3b2|SF3B2]]|0.418|
|[[:human genes:c:cdh24|CDH24]]|0.417|
|[[:human genes:t:tsg101|TSG101]]|0.417|
|[[:human genes:p:plk1|PLK1]]|0.417|
|[[:human genes:m:mcf2l|MCF2L]]|0.416|
|[[:human genes:t:tpx2|TPX2]]|0.416|
|[[:human genes:x:xab2|XAB2]]|0.415|
|[[:human genes:m:myt1l|MYT1L]]|0.415|
|[[:human genes:a:adra1d|ADRA1D]]|0.414|
|[[:human genes:v:vps28|VPS28]]|0.414|
|[[:human genes:c:ctr9|CTR9]]|0.414|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.414|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.414|
|[[:human genes:l:lrr1|LRR1]]|0.414|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.414|
|[[:human genes:t:tspy1|TSPY1]]|0.413|
|[[:human genes:i:ints6|INTS6]]|0.412|
|[[:human genes:r:rps19|RPS19]]|0.412|
|[[:human genes:p:pola1|POLA1]]|0.411|
|[[:human genes:v:vps54|VPS54]]|0.411|
|[[:human genes:s:syt9|SYT9]]|0.411|
|[[:human genes:k:krt78|KRT78]]|0.411|
|[[:human genes:s:sf3a2|SF3A2]]|0.41|
|[[:human genes:p:pigs|PIGS]]|0.41|
|[[:human genes:k:kctd17|KCTD17]]|0.409|
|[[:human genes:c:copa|COPA]]|0.408|
|[[:human genes:s:srrm2|SRRM2]]|0.407|
|[[:human genes:c:cdc45|CDC45]]|0.406|
|[[:human genes:a:arcn1|ARCN1]]|0.406|
|[[:human genes:n:nup155|NUP155]]|0.405|
|[[:human genes:t:tyms|TYMS]]|0.405|
|[[:human genes:n:nup153|NUP153]]|0.405|
|[[:human genes:p:psmd8|PSMD8]]|0.405|
|[[:human genes:k:kiaa1211|KIAA1211]]|0.405|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.404|
|[[:human genes:m:mms22l|MMS22L]]|0.404|
|[[:human genes:c:cgb2|CGB2]]|0.404|
|[[:human genes:p:phf2|PHF2]]|0.404|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.403|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.403|
|[[:human genes:s:sf3b5|SF3B5]]|0.402|
|[[:human genes:p:psma1|PSMA1]]|0.402|
|[[:human genes:d:ddx56|DDX56]]|0.402|
|[[:human genes:b:brd2|BRD2]]|0.402|
|[[:human genes:n:nup85|NUP85]]|0.401|
|[[:human genes:k:kpnb1|KPNB1]]|0.401|
|[[:human genes:d:dido1|DIDO1]]|0.401|
|[[:human genes:r:rps3a|RPS3A]]|0.4|
|[[:human genes:k:krt5|KRT5]]|0.4|
|[[:human genes:n:nup205|NUP205]]|0.4|
|[[:human genes:p:plk4|PLK4]]|0.4|
|[[:human genes:h:hivep3|HIVEP3]]|0.4|
|[[:human genes:g:gid4|GID4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 808
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNRPA1 Expression in NALM6 Cells: 6.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>