SNRPB2 [The Human Chemical-Genetic Interaction Map Project]

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======= SNRPB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNRPB2
  * **<color #00a2e8>Official Name</color>**: small nuclear ribonucleoprotein polypeptide B2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6629|6629]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08579|P08579]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNRPB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNRPB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603520|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A' protein.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|snRNP binding|
|U1 snRNA binding|
|U1 snRNP|
|U2 snRNP|
|U2-type catalytic step 2 spliceosome|
|U2-type precatalytic spliceosome|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|fibrillar center|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-3.21|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.82|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.66|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.75|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.42|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 128/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|12/28|
|blood|2/28|
|bone|4/26|
|breast|13/33|
|central nervous system|15/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|6/21|
|liver|3/20|
|lung|10/75|
|lymphocyte|3/16|
|ovary|4/26|
|pancreas|6/24|
|peripheral nervous system|1/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|7/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7999
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNRPB2 Expression in NALM6 Cells: 6.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>