SNRPD1 [The Human Chemical-Genetic Interaction Map Project]

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======= SNRPD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNRPD1
  * **<color #00a2e8>Official Name</color>**: small nuclear ribonucleoprotein D1 polypeptide
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6632|6632]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62314|P62314]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNRPD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNRPD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601063|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP- snRNP interactions through nonspecific electrostatic contacts with RNA. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:23333303}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LSM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|commitment complex|
|pICln-Sm protein complex|
|U1 snRNP binding|
|U4 snRNP|
|methylosome|
|small nuclear ribonucleoprotein complex|
|SMN-Sm protein complex|
|U5 snRNP|
|U1 snRNP|
|U2 snRNP|
|U12-type spliceosomal complex|
|U2-type catalytic step 2 spliceosome|
|U4/U6 x U5 tri-snRNP complex|
|spliceosomal snRNP assembly|
|U2-type precatalytic spliceosome|
|spliceosomal complex assembly|
|catalytic step 2 spliceosome|
|import into nucleus|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|nucleocytoplasmic transport|
|nuclear transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|RNA binding|
|intracellular transport|
|protein-containing complex assembly|
|RNA metabolic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.74|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.1|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.08|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.99|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.93|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.89|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.87|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.83|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.83|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.79|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.72|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.71|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.7|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.73|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.74|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.75|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.89|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.03|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.05|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.06|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1272
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNRPD1 Expression in NALM6 Cells: 6.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>