SNX33 [The Human Chemical-Genetic Interaction Map Project]

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======= SNX33 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNX33
  * **<color #00a2e8>Official Name</color>**: sorting nexin 33
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=257364|257364]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WV41|Q8WV41]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNX33&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNX33|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619107|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:18419754, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:20964629, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|BAR 3 WASP bdg|
|PX|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cleavage furrow formation|
|macropinocytosis|
|pinocytosis|
|negative regulation of protein localization to cell surface|
|positive regulation of membrane protein ectodomain proteolysis|
|plasma membrane tubulation|
|positive regulation of protein localization to cell surface|
|regulation of membrane protein ectodomain proteolysis|
|cytokinetic process|
|regulation of protein localization to cell surface|
|negative regulation of endocytosis|
|extrinsic component of membrane|
|mitotic cytokinesis|
|endosome organization|
|phosphatidylinositol binding|
|plasma membrane organization|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|negative regulation of cellular protein localization|
|plasma membrane invagination|
|protein import|
|cytoplasmic vesicle membrane|
|membrane invagination|
|regulation of endocytosis|
|positive regulation of protein catabolic process|
|endosomal transport|
|cytoplasmic vesicle|
|vesicle organization|
|positive regulation of cellular protein localization|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|endomembrane system organization|
|positive regulation of catabolic process|
|negative regulation of transport|
|cell division|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|endocytosis|
|mitotic cell cycle process|
|import into cell|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|regulation of cellular catabolic process|
|membrane organization|
|regulation of cellular localization|
|intracellular protein transport|
|regulation of catabolic process|
|cell cycle process|
|regulation of protein localization|
|identical protein binding|
|cell cycle|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of protein metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.91|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.91|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.15|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5660
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNX33 Expression in NALM6 Cells: 2.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>