SNX6 [The Human Chemical-Genetic Interaction Map Project]

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======= SNX6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SNX6
  * **<color #00a2e8>Official Name</color>**: sorting nexin 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58533|58533]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNH7|Q9UNH7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SNX6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SNX6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606098|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). {ECO:0000250|UniProtKB:Q6P8X1, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774, ECO:0000269|PubMed:20354142, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:19935774, ECO:0000303|PubMed:20830743, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BAR|
|PX|
|Vps5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retromer, tubulation complex|
|tubular endosome|
|regulation of histamine secretion by mast cell|
|dynactin binding|
|negative regulation of epidermal growth factor-activated receptor activity|
|retromer complex|
|regulation of epidermal growth factor-activated receptor activity|
|negative regulation of protein tyrosine kinase activity|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|cellular response to amyloid-beta|
|regulation of mast cell activation|
|negative regulation of epidermal growth factor receptor signaling pathway|
|regulation of leukocyte degranulation|
|response to amyloid-beta|
|negative regulation of ERBB signaling pathway|
|negative regulation of peptidyl-tyrosine phosphorylation|
|regulation of myeloid leukocyte mediated immunity|
|negative regulation of signaling receptor activity|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|regulation of epidermal growth factor receptor signaling pathway|
|phosphatidylinositol binding|
|regulation of protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|retrograde transport, endosome to Golgi|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of neurotransmitter transport|
|cytosolic transport|
|negative regulation of neuron apoptotic process|
|negative regulation of cellular response to growth factor stimulus|
|early endosome membrane|
|regulation of regulated secretory pathway|
|regulation of macroautophagy|
|regulation of signaling receptor activity|
|regulation of leukocyte mediated immunity|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|positive regulation of immune effector process|
|regulation of exocytosis|
|negative regulation of protein kinase activity|
|endosomal transport|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of hormone secretion|
|endosome|
|regulation of cellular response to growth factor stimulus|
|negative regulation of transferase activity|
|regulation of neuron death|
|cellular response to peptide|
|regulation of autophagy|
|regulation of inflammatory response|
|regulation of intracellular transport|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|regulation of immune effector process|
|response to peptide|
|protein heterodimerization activity|
|regulation of hormone levels|
|regulation of vesicle-mediated transport|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|regulation of cell activation|
|cellular response to nitrogen compound|
|regulation of ion transport|
|regulation of secretion by cell|
|regulation of defense response|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|regulation of transferase activity|
|intracellular protein transport|
|negative regulation of cell death|
|regulation of catabolic process|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16224
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SNX6 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>