SOAT1 [The Human Chemical-Genetic Interaction Map Project]

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======= SOAT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOAT1
  * **<color #00a2e8>Official Name</color>**: sterol O-acyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6646|6646]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35610|P35610]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOAT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOAT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/102642|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MBOAT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sterol O-acyltransferase activity|
|cholesterol storage|
|cholesterol O-acyltransferase activity|
|positive regulation of amyloid precursor protein biosynthetic process|
|cholesterol esterification|
|sterol esterification|
|steroid esterification|
|macrophage derived foam cell differentiation|
|foam cell differentiation|
|very-low-density lipoprotein particle assembly|
|regulation of amyloid precursor protein biosynthetic process|
|positive regulation of glycoprotein biosynthetic process|
|fatty-acyl-CoA binding|
|positive regulation of glycoprotein metabolic process|
|cholesterol efflux|
|low-density lipoprotein particle clearance|
|plasma lipoprotein particle assembly|
|lipid storage|
|protein-lipid complex assembly|
|plasma lipoprotein particle clearance|
|regulation of glycoprotein biosynthetic process|
|plasma lipoprotein particle organization|
|regulation of glycoprotein metabolic process|
|protein-lipid complex subunit organization|
|cholesterol binding|
|cholesterol transport|
|sterol transport|
|regulation of plasma lipoprotein particle levels|
|cholesterol homeostasis|
|sterol homeostasis|
|cholesterol metabolic process|
|secondary alcohol metabolic process|
|lipid homeostasis|
|sterol metabolic process|
|organic hydroxy compound transport|
|maintenance of location|
|lipid modification|
|steroid metabolic process|
|lipid transport|
|alcohol metabolic process|
|lipid localization|
|extracellular structure organization|
|organic hydroxy compound metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|chemical homeostasis|
|lipid metabolic process|
|protein-containing complex assembly|
|homeostatic process|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.99|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13230
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOAT1 Expression in NALM6 Cells: 6.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>