SOSTDC1 [The Human Chemical-Genetic Interaction Map Project]

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======= SOSTDC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOSTDC1
  * **<color #00a2e8>Official Name</color>**: sclerostin domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25928|25928]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6X4U4|Q6X4U4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOSTDC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOSTDC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609675|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. {ECO:0000250, ECO:0000269|PubMed:15020244}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sclerostin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of determination of dorsal identity|
|mammary gland bud morphogenesis|
|regulation of determination of dorsal identity|
|BMP receptor activity|
|morphogenesis of an epithelial bud|
|BMP binding|
|negative regulation of cell fate commitment|
|morphogenesis of an epithelial fold|
|hair follicle morphogenesis|
|negative regulation of myoblast differentiation|
|regulation of cell fate commitment|
|epidermis morphogenesis|
|mammary gland duct morphogenesis|
|mammary gland morphogenesis|
|negative regulation of BMP signaling pathway|
|regulation of myoblast differentiation|
|mammary gland epithelium development|
|hair follicle development|
|skin epidermis development|
|hair cycle process|
|molting cycle process|
|odontogenesis of dentin-containing tooth|
|regulation of BMP signaling pathway|
|BMP signaling pathway|
|molting cycle|
|hair cycle|
|gland morphogenesis|
|cellular response to BMP stimulus|
|response to BMP|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|odontogenesis|
|mammary gland development|
|negative regulation of cellular response to growth factor stimulus|
|negative regulation of canonical Wnt signaling pathway|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of Wnt signaling pathway|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to growth factor stimulus|
|regulation of canonical Wnt signaling pathway|
|epithelial tube morphogenesis|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|skin development|
|gland development|
|epidermis development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|pattern specification process|
|cellular response to growth factor stimulus|
|response to growth factor|
|tissue morphogenesis|
|tube morphogenesis|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|tube development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|epithelium development|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|extracellular space|
|negative regulation of response to stimulus|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.71|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.72|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.72|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.72|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.76|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.76|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.78|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.81|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.98|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.11|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9801
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOSTDC1 Expression in NALM6 Cells: -3.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>