SOX2 [The Human Chemical-Genetic Interaction Map Project]

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======= SOX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOX2
  * **<color #00a2e8>Official Name</color>**: SRY-box transcription factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6657|6657]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48431|P48431]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/184429|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18035408}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
|SOXp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endodermal cell fate specification|
|endodermal cell fate commitment|
|adenohypophysis development|
|glial cell fate commitment|
|neuronal stem cell population maintenance|
|nuclear transcription factor complex|
|cell fate commitment involved in formation of primary germ layer|
|miRNA binding|
|endodermal cell differentiation|
|pituitary gland development|
|endoderm formation|
|tissue regeneration|
|somatic stem cell population maintenance|
|endoderm development|
|diencephalon development|
|transcription regulatory region sequence-specific DNA binding|
|cell fate specification|
|formation of primary germ layer|
|endocrine system development|
|negative regulation of epithelial cell proliferation|
|osteoblast differentiation|
|stem cell population maintenance|
|maintenance of cell number|
|cell cycle arrest|
|regeneration|
|gastrulation|
|glial cell differentiation|
|negative regulation of canonical Wnt signaling pathway|
|inner ear development|
|transcription factor complex|
|negative regulation of Wnt signaling pathway|
|gliogenesis|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|transcription regulatory region DNA binding|
|ear development|
|negative regulation of neuron differentiation|
|regulation of cysteine-type endopeptidase activity|
|cell fate commitment|
|positive regulation of cell-cell adhesion|
|ossification|
|regulation of canonical Wnt signaling pathway|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|negative regulation of cell development|
|regulation of epithelial cell proliferation|
|eye development|
|regulation of Wnt signaling pathway|
|visual system development|
|sensory system development|
|forebrain development|
|developmental growth|
|growth|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|gland development|
|regulation of endopeptidase activity|
|sequence-specific DNA binding|
|regulation of peptidase activity|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|wound healing|
|response to growth factor|
|positive regulation of MAPK cascade|
|sensory organ development|
|embryonic morphogenesis|
|response to wounding|
|negative regulation of cell cycle|
|regulation of neuron differentiation|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|regulation of cell adhesion|
|chromatin organization|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|brain development|
|regulation of MAPK cascade|
|head development|
|regulation of neurogenesis|
|negative regulation of transcription by RNA polymerase II|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|cell cycle process|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|chromosome organization|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12441
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOX2 Expression in NALM6 Cells: -2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>