SOX7 [The Human Chemical-Genetic Interaction Map Project]

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======= SOX7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SOX7
  * **<color #00a2e8>Official Name</color>**: SRY-box transcription factor 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83595|83595]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BT81|Q9BT81]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SOX7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SOX7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612202|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3'. {ECO:0000250, ECO:0000269|PubMed:18819930}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
|DUF3547|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear transcription factor complex|
|endoderm formation|
|endoderm development|
|formation of primary germ layer|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cysteine-type endopeptidase activity|
|gastrulation|
|positive regulation of endopeptidase activity|
|positive regulation of peptidase activity|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|transcription regulatory region DNA binding|
|regulation of cysteine-type endopeptidase activity|
|regulation of canonical Wnt signaling pathway|
|positive regulation of proteolysis|
|regulation of Wnt signaling pathway|
|regulation of endopeptidase activity|
|sequence-specific DNA binding|
|regulation of peptidase activity|
|embryonic morphogenesis|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|positive regulation of cell death|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|negative regulation of transcription by RNA polymerase II|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.86|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.66|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.35|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.25|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.17|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.08|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.05|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-2|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.96|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.92|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.89|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.79|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.78|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.76|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.76|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.75|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.73|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.71|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.7|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.76|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.01|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.15|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lmo2|LMO2]]|0.549|
|[[:human genes:z:zfx|ZFX]]|0.484|
|[[:human genes:s:ssbp2|SSBP2]]|0.483|
|[[:human genes:c:cbfb|CBFB]]|0.481|
|[[:human genes:i:id3|ID3]]|0.476|
|[[:human genes:n:nsd1|NSD1]]|0.471|
|[[:human genes:m:maml1|MAML1]]|0.467|
|[[:human genes:r:rnmt|RNMT]]|0.464|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.455|
|[[:human genes:c:ccdc101|CCDC101]]|0.444|
|[[:human genes:t:trmt10a|TRMT10A]]|0.443|
|[[:human genes:f:fli1|FLI1]]|0.428|
|[[:human genes:z:znf592|ZNF592]]|0.426|
|[[:human genes:b:bap1|BAP1]]|0.424|
|[[:human genes:p:pmm2|PMM2]]|0.422|
|[[:human genes:s:smg9|SMG9]]|0.421|
|[[:human genes:d:dohh|DOHH]]|0.42|
|[[:human genes:e:erg|ERG]]|0.42|
|[[:human genes:d:dpagt1|DPAGT1]]|0.419|
|[[:human genes:d:dnajc3|DNAJC3]]|0.413|
|[[:human genes:r:runx1|RUNX1]]|0.409|
|[[:human genes:r:rptor|RPTOR]]|0.407|
|[[:human genes:p:parl|PARL]]|0.405|
|[[:human genes:s:scaf8|SCAF8]]|0.404|
|[[:human genes:a:asxl2|ASXL2]]|0.402|
|[[:human genes:i:itpr3|ITPR3]]|0.402|
|[[:human genes:a:atf7ip|ATF7IP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14945
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SOX7 Expression in NALM6 Cells: 4.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>