SP100 [The Human Chemical-Genetic Interaction Map Project]

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======= SP100 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SP100
  * **<color #00a2e8>Official Name</color>**: SP100 nuclear antigen
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6672|6672]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23497|P23497]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SP100&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SP100|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604585|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
|Sp100|
|Bromodomain|
|SAND|
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of Fas signaling pathway|
|negative regulation of protein export from nucleus|
|chromo shadow domain binding|
|Mre11 complex|
|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|
|DNA damage response, signal transduction resulting in transcription|
|negative regulation of nucleocytoplasmic transport|
|maintenance of protein location in nucleus|
|regulation of protein export from nucleus|
|maintenance of protein localization in organelle|
|negative regulation of intracellular protein transport|
|negative regulation of endothelial cell migration|
|negative regulation of DNA binding|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of intracellular transport|
|cellular response to type I interferon|
|negative regulation of epithelial cell migration|
|type I interferon signaling pathway|
|response to type I interferon|
|interferon-gamma-mediated signaling pathway|
|maintenance of protein location in cell|
|DNA damage response, signal transduction by p53 class mediator|
|kinase binding|
|maintenance of location in cell|
|telomere maintenance|
|PML body|
|telomere organization|
|signal transduction in response to DNA damage|
|regulation of nucleocytoplasmic transport|
|maintenance of protein location|
|nuclear chromosome, telomeric region|
|negative regulation of cellular protein localization|
|signal transduction by p53 class mediator|
|regulation of DNA binding|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of endothelial cell migration|
|protein dimerization activity|
|negative regulation of DNA-binding transcription factor activity|
|cellular response to interferon-gamma|
|protein localization to nucleus|
|maintenance of location|
|negative regulation of binding|
|negative regulation of protein transport|
|response to interferon-gamma|
|negative regulation of establishment of protein localization|
|regulation of epithelial cell migration|
|regulation of intracellular protein transport|
|protein domain specific binding|
|negative regulation of cell migration|
|negative regulation of cell motility|
|nuclear body|
|regulation of angiogenesis|
|negative regulation of cellular component movement|
|regulation of vasculature development|
|negative regulation of locomotion|
|anatomical structure homeostasis|
|regulation of intracellular transport|
|regulation of binding|
|regulation of apoptotic signaling pathway|
|regulation of DNA-binding transcription factor activity|
|negative regulation of transport|
|regulation of cellular protein localization|
|cytokine-mediated signaling pathway|
|viral process|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|DNA metabolic process|
|regulation of establishment of protein localization|
|innate immune response|
|cellular response to DNA damage stimulus|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|regulation of cell motility|
|regulation of cellular localization|
|defense response to other organism|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|response to cytokine|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.86|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.81|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15007
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SP100 Expression in NALM6 Cells: 6.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>