SPARC [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= SPARC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPARC
  * **<color #00a2e8>Official Name</color>**: secreted protein acidic and cysteine rich
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6678|6678]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09486|P09486]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPARC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPARC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182120|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kazal 2|
|SPARC Ca bdg|
|FOLN|
|Kazal 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to L-ascorbic acid|
|response to gravity|
|platelet alpha granule|
|endocytic vesicle lumen|
|platelet alpha granule membrane|
|response to lead ion|
|extracellular matrix binding|
|negative regulation of endothelial cell proliferation|
|response to cadmium ion|
|collagen binding|
|platelet alpha granule lumen|
|response to vitamin|
|basement membrane|
|pigmentation|
|response to cAMP|
|positive regulation of endothelial cell migration|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|nuclear matrix|
|negative regulation of vasculature development|
|negative regulation of epithelial cell proliferation|
|response to ethanol|
|platelet degranulation|
|regulation of endothelial cell proliferation|
|extracellular matrix structural constituent|
|response to organophosphorus|
|positive regulation of epithelial cell migration|
|response to glucocorticoid|
|response to monosaccharide|
|response to calcium ion|
|response to purine-containing compound|
|regulation of endothelial cell migration|
|response to corticosteroid|
|lung development|
|response to carbohydrate|
|respiratory tube development|
|inner ear development|
|respiratory system development|
|bone development|
|response to nutrient|
|regulation of synapse organization|
|regulation of epithelial cell migration|
|ear development|
|regulation of synapse structure or activity|
|response to alcohol|
|receptor-mediated endocytosis|
|ossification|
|regulation of angiogenesis|
|response to antibiotic|
|response to lipopolysaccharide|
|regulation of vasculature development|
|response to molecule of bacterial origin|
|response to steroid hormone|
|regulation of epithelial cell proliferation|
|extracellular matrix organization|
|response to acid chemical|
|glutamatergic synapse|
|collagen-containing extracellular matrix|
|response to metal ion|
|extracellular structure organization|
|response to peptide hormone|
|response to peptide|
|wound healing|
|regulation of cell morphogenesis|
|skeletal system development|
|response to nutrient levels|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|response to toxic substance|
|positive regulation of cell motility|
|heart development|
|response to extracellular stimulus|
|response to growth factor|
|response to inorganic substance|
|positive regulation of cellular component movement|
|sensory organ development|
|positive regulation of locomotion|
|endocytosis|
|response to wounding|
|cell surface|
|import into cell|
|negative regulation of cell population proliferation|
|response to bacterium|
|regulated exocytosis|
|calcium ion binding|
|exocytosis|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|negative regulation of developmental process|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|export from cell|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|response to cytokine|
|secretion|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|mitochondrion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|positive regulation of multicellular organismal process|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.98|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.87|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.72|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11461
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPARC Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>