SPC25 [The Human Chemical-Genetic Interaction Map Project]

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======= SPC25 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPC25
  * **<color #00a2e8>Official Name</color>**: SPC25 component of NDC80 kinetochore complex
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57405|57405]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HBM1|Q9HBM1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPC25&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPC25|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609395|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:23085020}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spc7|
|Spindle Spc25|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ndc80 complex|
|mitotic spindle organization|
|condensed chromosome kinetochore|
|microtubule cytoskeleton organization involved in mitosis|
|spindle organization|
|chromosome segregation|
|microtubule cytoskeleton organization|
|cell division|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|cell cycle process|
|cytoskeleton organization|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.77|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.74|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.74|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.88|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.15|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.42|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2.46|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|2.49|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:casc5|CASC5]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 682/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|25/26|
|breast|30/33|
|central nervous system|50/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|17/21|
|liver|19/20|
|lung|70/75|
|lymphocyte|15/16|
|ovary|22/26|
|pancreas|24/24|
|peripheral nervous system|14/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1078
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPC25 Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>