SPG21 [The Human Chemical-Genetic Interaction Map Project]

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======= SPG21 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPG21
  * **<color #00a2e8>Official Name</color>**: SPG21 abhydrolase domain containing, maspardin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51324|51324]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZD8|Q9NZD8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPG21&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPG21|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608181|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role as a negative regulatory factor in CD4- dependent T-cell activation. {ECO:0000269|PubMed:11113139}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 1|
|Abhydrolase 5|
|Abhydrolase 6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CD4 receptor binding|
|trans-Golgi network transport vesicle|
|endosome membrane|
|antigen receptor-mediated signaling pathway|
|immune response-activating cell surface receptor signaling pathway|
|immune response-regulating cell surface receptor signaling pathway|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|activation of immune response|
|intracellular membrane-bounded organelle|
|positive regulation of immune response|
|Golgi apparatus|
|positive regulation of immune system process|
|regulation of immune response|
|regulation of immune system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.94|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.72|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.77|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.85|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.86|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.91|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.32|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.35|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8941
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPG21 Expression in NALM6 Cells: 6.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>