SPN [The Human Chemical-Genetic Interaction Map Project]

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======= SPN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPN
  * **<color #00a2e8>Official Name</color>**: sialophorin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6693|6693]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16150|P16150]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182160|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T- cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter- receptor for SIGLEC1 (By similarity). {ECO:0000250|UniProtKB:P15702, ECO:0000269|PubMed:18036228, ECO:0000269|PubMed:24328034}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|T-helper 1 cell lineage commitment|
|T-helper 1 cell differentiation|
|T-helper cell lineage commitment|
|CD4-positive, alpha-beta T cell lineage commitment|
|uropod|
|alpha-beta T cell lineage commitment|
|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|
|leukocyte tethering or rolling|
|T-helper 1 type immune response|
|leukocyte adhesion to vascular endothelial cell|
|interferon-gamma production|
|positive regulation of tumor necrosis factor biosynthetic process|
|T cell lineage commitment|
|positive T cell selection|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|T-helper cell differentiation|
|alpha-beta T cell activation involved in immune response|
|alpha-beta T cell differentiation involved in immune response|
|regulation of tumor necrosis factor biosynthetic process|
|positive regulation of T cell migration|
|T cell differentiation involved in immune response|
|CD4-positive, alpha-beta T cell differentiation|
|positive regulation of lymphocyte migration|
|CD4-positive, alpha-beta T cell activation|
|T cell selection|
|cellular extravasation|
|Hsp70 protein binding|
|regulation of T cell migration|
|leukocyte cell-cell adhesion|
|alpha-beta T cell differentiation|
|cellular defense response|
|heat shock protein binding|
|negative regulation of T cell proliferation|
|alpha-beta T cell activation|
|regulation of lymphocyte migration|
|microvillus|
|T cell activation involved in immune response|
|positive regulation of cytokine biosynthetic process|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of leukocyte proliferation|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|PML body|
|regulation of cytokine biosynthetic process|
|negative regulation of T cell activation|
|lymphocyte activation involved in immune response|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of leukocyte migration|
|T cell differentiation|
|transmembrane signaling receptor activity|
|negative regulation of lymphocyte activation|
|regulation of tumor necrosis factor production|
|cytokine production|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of T cell proliferation|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|regulation of leukocyte migration|
|establishment or maintenance of cell polarity|
|negative regulation of cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|T cell activation|
|lymphocyte differentiation|
|cell fate commitment|
|negative regulation of cell adhesion|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|defense response to bacterium|
|leukocyte differentiation|
|leukocyte migration|
|lymphocyte activation|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|positive regulation of cell migration|
|cell-cell adhesion|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|hemopoiesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|immune system development|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of cell migration|
|regulation of cell motility|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|extracellular space|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.434|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7417
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPN Expression in NALM6 Cells: 8.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>