SPRY2 [The Human Chemical-Genetic Interaction Map Project]

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======= SPRY2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPRY2
  * **<color #00a2e8>Official Name</color>**: sprouty RTK signaling antagonist 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10253|10253]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43597|O43597]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPRY2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPRY2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602466|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. {ECO:0000269|PubMed:10887178}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sprouty|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of neurotrophin TRK receptor signaling pathway|
|lung growth|
|bud elongation involved in lung branching|
|negative regulation of vascular endothelial growth factor signaling pathway|
|protein serine/threonine kinase inhibitor activity|
|negative regulation of cellular response to vascular endothelial growth factor stimulus|
|regulation of neurotrophin TRK receptor signaling pathway|
|negative regulation of fibroblast growth factor receptor signaling pathway|
|branch elongation of an epithelium|
|regulation of vascular endothelial growth factor signaling pathway|
|regulation of cellular response to vascular endothelial growth factor stimulus|
|negative regulation of peptidyl-threonine phosphorylation|
|epithelial tube branching involved in lung morphogenesis|
|axis elongation|
|establishment of mitotic spindle orientation|
|protein serine/threonine kinase activator activity|
|regulation of fibroblast growth factor receptor signaling pathway|
|establishment of mitotic spindle localization|
|establishment of spindle orientation|
|cellular response to vascular endothelial growth factor stimulus|
|lung morphogenesis|
|establishment of spindle localization|
|regulation of peptidyl-threonine phosphorylation|
|negative regulation of epidermal growth factor receptor signaling pathway|
|negative regulation of GTPase activity|
|spindle localization|
|negative regulation of ERBB signaling pathway|
|negative regulation of Ras protein signal transduction|
|negative regulation of small GTPase mediated signal transduction|
|negative regulation of ERK1 and ERK2 cascade|
|negative regulation of MAP kinase activity|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of ERBB signaling pathway|
|ruffle membrane|
|organ growth|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|inner ear morphogenesis|
|negative regulation of angiogenesis|
|microtubule cytoskeleton organization involved in mitosis|
|negative regulation of blood vessel morphogenesis|
|positive regulation of peptidyl-serine phosphorylation|
|developmental growth involved in morphogenesis|
|negative regulation of vasculature development|
|ear morphogenesis|
|establishment of cell polarity|
|branching morphogenesis of an epithelial tube|
|negative regulation of protein serine/threonine kinase activity|
|regulation of peptidyl-serine phosphorylation|
|sensory perception of sound|
|negative regulation of cellular response to growth factor stimulus|
|microtubule cytoskeleton|
|morphogenesis of a branching epithelium|
|positive regulation of protein kinase B signaling|
|sensory perception of mechanical stimulus|
|negative regulation of MAPK cascade|
|morphogenesis of a branching structure|
|lung development|
|respiratory tube development|
|negative regulation of cell projection organization|
|inner ear development|
|respiratory system development|
|establishment or maintenance of cell polarity|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of protein kinase B signaling|
|ear development|
|negative regulation of protein kinase activity|
|regulation of Ras protein signal transduction|
|negative regulation of kinase activity|
|cell fate commitment|
|sensory organ morphogenesis|
|regulation of cellular response to growth factor stimulus|
|negative regulation of transferase activity|
|regulation of angiogenesis|
|embryonic organ morphogenesis|
|regulation of ERK1 and ERK2 cascade|
|epithelial tube morphogenesis|
|microtubule|
|regulation of vasculature development|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|establishment of organelle localization|
|cytoskeleton|
|developmental growth|
|growth|
|negative regulation of protein phosphorylation|
|morphogenesis of an epithelium|
|embryonic organ development|
|negative regulation of phosphorylation|
|negative regulation of hydrolase activity|
|protein kinase binding|
|microtubule cytoskeleton organization|
|regulation of GTPase activity|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|sensory organ development|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|organelle localization|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|tube morphogenesis|
|positive regulation of transferase activity|
|microtubule-based process|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|negative regulation of developmental process|
|animal organ morphogenesis|
|sensory perception|
|regulation of transferase activity|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|cell cycle process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|response to cytokine|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|system process|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12182
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPRY2 Expression in NALM6 Cells: 4.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>