SPTA1 [The Human Chemical-Genetic Interaction Map Project]

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======= SPTA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPTA1
  * **<color #00a2e8>Official Name</color>**: spectrin alpha, erythrocytic 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6708|6708]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02549|P02549]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SPTA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SPTA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182860|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of molecular scaffold proteins that link the plasma membrane to the actin cytoskeleton and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms a component of the erythrocyte plasma membrane. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis-2, pyropoikilocytosis, and spherocytosis, type 3. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand Ca insen|
|Spectrin|
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intrinsic component of the cytoplasmic side of the plasma membrane|
|spectrin-associated cytoskeleton|
|spectrin|
|cuticular plate|
|porphyrin-containing compound biosynthetic process|
|tetrapyrrole biosynthetic process|
|actin filament capping|
|negative regulation of actin filament depolymerization|
|porphyrin-containing compound metabolic process|
|regulation of actin filament depolymerization|
|negative regulation of actin filament polymerization|
|lymphocyte homeostasis|
|tetrapyrrole metabolic process|
|negative regulation of protein depolymerization|
|negative regulation of protein polymerization|
|leukocyte homeostasis|
|negative regulation of protein complex disassembly|
|regulation of protein depolymerization|
|plasma membrane organization|
|positive regulation of protein binding|
|positive regulation of T cell proliferation|
|structural constituent of cytoskeleton|
|regulation of protein complex disassembly|
|positive regulation of lymphocyte proliferation|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|negative regulation of cytoskeleton organization|
|regulation of cell shape|
|regulation of T cell proliferation|
|regulation of actin filament polymerization|
|positive regulation of binding|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|actin filament binding|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cofactor biosynthetic process|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|actin cytoskeleton|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of protein binding|
|regulation of leukocyte proliferation|
|regulation of protein polymerization|
|actin filament organization|
|positive regulation of cell-cell adhesion|
|axon guidance|
|regulation of actin filament organization|
|neuron projection guidance|
|axon|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|positive regulation of lymphocyte activation|
|MAPK cascade|
|axonogenesis|
|Golgi vesicle transport|
|negative regulation of organelle organization|
|regulation of binding|
|regulation of cellular component size|
|regulation of actin filament-based process|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|axon development|
|positive regulation of cell activation|
|endomembrane system organization|
|cell morphogenesis involved in neuron differentiation|
|cofactor metabolic process|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|protein heterodimerization activity|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|cell part morphogenesis|
|regulation of lymphocyte activation|
|regulation of anatomical structure size|
|regulation of cytoskeleton organization|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|actin filament-based process|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|neuron projection development|
|regulation of cell adhesion|
|negative regulation of cellular component organization|
|calcium ion binding|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|membrane organization|
|positive regulation of cell population proliferation|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|locomotion|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of molecular function|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17113
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SPTA1 Expression in NALM6 Cells: 2.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>