SQSTM1 [The Human Chemical-Genetic Interaction Map Project]

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======= SQSTM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SQSTM1
  * **<color #00a2e8>Official Name</color>**: sequestosome 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8878|8878]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13501|Q13501]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SQSTM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SQSTM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601530|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). {ECO:0000250|UniProtKB:O08623, ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28404643}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ZZ|
|PB1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to perinuclear region of cytoplasm|
|amphisome|
|Lewy body|
|mitophagy|
|aggrephagy|
|autolysosome|
|regulation of protein complex stability|
|response to mitochondrial depolarisation|
|inclusion body|
|positive regulation of long-term synaptic potentiation|
|sperm midpiece|
|K63-linked polyubiquitin modification-dependent protein binding|
|selective autophagy|
|phagophore assembly site|
|ionotropic glutamate receptor binding|
|SH2 domain binding|
|mitochondrion disassembly|
|autophagy of mitochondrion|
|aggresome|
|regulation of long-term synaptic potentiation|
|response to ischemia|
|sarcomere|
|protein kinase C binding|
|positive regulation of protein localization to plasma membrane|
|receptor tyrosine kinase binding|
|positive regulation of protein localization to cell periphery|
|organelle disassembly|
|autophagosome|
|endosome organization|
|ubiquitin binding|
|P-body|
|regulation of protein localization to plasma membrane|
|interleukin-1-mediated signaling pathway|
|PML body|
|protein heterooligomerization|
|regulation of protein localization to cell periphery|
|positive regulation of protein localization to membrane|
|late endosome|
|positive regulation of synaptic transmission|
|macroautophagy|
|cellular response to interleukin-1|
|regulation of mitochondrion organization|
|regulation of synaptic plasticity|
|regulation of protein localization to membrane|
|response to interleukin-1|
|endosomal transport|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of Ras protein signal transduction|
|autophagy|
|process utilizing autophagic mechanism|
|ubiquitin protein ligase binding|
|vesicle organization|
|positive regulation of cellular protein localization|
|regulation of small GTPase mediated signal transduction|
|enzyme binding|
|protein serine/threonine kinase activity|
|cellular component disassembly|
|endomembrane system organization|
|modulation of chemical synaptic transmission|
|mitochondrion organization|
|regulation of trans-synaptic signaling|
|protein kinase binding|
|protein complex oligomerization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|positive regulation of cell death|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|apoptotic process|
|protein phosphorylation|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|macromolecule catabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|identical protein binding|
|cell death|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|proteolysis|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12148
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SQSTM1 Expression in NALM6 Cells: 5.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>