SRGAP2 [The Human Chemical-Genetic Interaction Map Project]

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======= SRGAP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRGAP2
  * **<color #00a2e8>Official Name</color>**: SLIT-ROBO Rho GTPase activating protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23380|23380]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75044|O75044]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRGAP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRGAP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606524|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. {ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21148482, ECO:0000269|PubMed:22559944}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
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<modal id='GO_terms' size='lg' title='GO Terms'>
|lamellipodium assembly involved in ameboidal cell migration|
|extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration|
|pseudopodium assembly|
|pseudopodium organization|
|modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration|
|cell motility involved in cerebral cortex radial glia guided migration|
|dendritic spine head|
|actin filament severing|
|negative regulation of neuron migration|
|filopodium assembly|
|cerebral cortex radial glia guided migration|
|telencephalon glial cell migration|
|dendritic spine development|
|cerebral cortex radially oriented cell migration|
|lamellipodium assembly|
|glial cell migration|
|lamellipodium organization|
|regulation of neuron migration|
|cerebral cortex cell migration|
|substrate adhesion-dependent cell spreading|
|Rac GTPase binding|
|telencephalon cell migration|
|phagocytic vesicle|
|forebrain cell migration|
|dendrite development|
|cerebral cortex development|
|ameboidal-type cell migration|
|pallium development|
|lamellipodium|
|cell-substrate adhesion|
|postsynaptic membrane|
|gliogenesis|
|postsynaptic density|
|telencephalon development|
|negative regulation of cell migration|
|negative regulation of cell motility|
|GTPase activator activity|
|negative regulation of neurogenesis|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|negative regulation of cell development|
|regulation of small GTPase mediated signal transduction|
|forebrain development|
|positive regulation of GTPase activity|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|cell junction|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|neuron projection development|
|microtubule-based process|
|negative regulation of cell differentiation|
|cell morphogenesis|
|brain development|
|positive regulation of hydrolase activity|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|protein homodimerization activity|
|regulation of cell motility|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|central nervous system development|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|neuron differentiation|
|identical protein binding|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|locomotion|
|positive regulation of catalytic activity|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|regulation of cell death|
|positive regulation of molecular function|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4368
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRGAP2 Expression in NALM6 Cells: 6.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
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