SRR [The Human Chemical-Genetic Interaction Map Project]

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======= SRR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRR
  * **<color #00a2e8>Official Name</color>**: serine racemase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63826|63826]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZT4|Q9GZT4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606477|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. {ECO:0000269|PubMed:11054547, ECO:0000269|PubMed:20106978}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PALP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|serine racemase activity|
|D-amino acid biosynthetic process|
|threonine racemase activity|
|D-serine biosynthetic process|
|D-serine ammonia-lyase activity|
|D-serine metabolic process|
|L-serine ammonia-lyase activity|
|D-amino acid metabolic process|
|pyruvate biosynthetic process|
|L-serine biosynthetic process|
|L-serine metabolic process|
|glycine binding|
|serine family amino acid biosynthetic process|
|response to morphine|
|response to isoquinoline alkaloid|
|serine family amino acid metabolic process|
|pyridoxal phosphate binding|
|alpha-amino acid biosynthetic process|
|pyruvate metabolic process|
|apical part of cell|
|response to anesthetic|
|cellular amino acid biosynthetic process|
|PDZ domain binding|
|protein homotetramerization|
|response to alkaloid|
|protein tetramerization|
|response to ammonium ion|
|monocarboxylic acid biosynthetic process|
|alpha-amino acid metabolic process|
|magnesium ion binding|
|aging|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|protein homooligomerization|
|neuronal cell body|
|drug metabolic process|
|protein complex oligomerization|
|monocarboxylic acid metabolic process|
|small molecule biosynthetic process|
|response to bacterium|
|calcium ion binding|
|brain development|
|head development|
|response to lipid|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|central nervous system development|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|response to nitrogen compound|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|organonitrogen compound biosynthetic process|
|ATP binding|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|small molecule metabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8964
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRR Expression in NALM6 Cells: 4.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>