SRRM2 [The Human Chemical-Genetic Interaction Map Project]

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======= SRRM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRRM2
  * **<color #00a2e8>Official Name</color>**: serine/arginine repetitive matrix 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23524|23524]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UQ35|Q9UQ35]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRRM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRRM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606032|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|cwf21|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|C2H2 zinc finger domain binding|
|U2-type catalytic step 2 spliceosome|
|U2-type precatalytic spliceosome|
|Cajal body|
|catalytic step 2 spliceosome|
|protein N-terminus binding|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pcf11|PCF11]]|0.446|
|[[:human genes:c:cwc22|CWC22]]|0.437|
|[[:human genes:r:rps9|RPS9]]|0.431|
|[[:human genes:x:xpo1|XPO1]]|0.423|
|[[:human genes:a:axin1|AXIN1]]|0.421|
|[[:human genes:c:cbwd3|CBWD3]]|0.42|
|[[:human genes:n:ndc80|NDC80]]|0.416|
|[[:human genes:r:rps12|RPS12]]|0.414|
|[[:human genes:v:vasn|VASN]]|0.408|
|[[:human genes:r:rbbp5|RBBP5]]|0.408|
|[[:human genes:s:s1pr4|S1PR4]]|0.408|
|[[:human genes:s:ssh2|SSH2]]|0.407|
|[[:human genes:s:snrpa1|SNRPA1]]|0.407|
|[[:human genes:c:c14orf93|C14orf93]]|0.406|
|[[:human genes:c:cbwd5|CBWD5]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 35/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|4/26|
|breast|2/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|3/20|
|lung|4/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 425
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRRM2 Expression in NALM6 Cells: 10.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>