SRSF3 [The Human Chemical-Genetic Interaction Map Project]

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======= SRSF3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRSF3
  * **<color #00a2e8>Official Name</color>**: serine and arginine rich splicing factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6428|6428]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P84103|P84103]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRSF3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRSF3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603364|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Splicing factor that specifically promotes exon- inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export such as of histone H2A (PubMed:11336712, PubMed:18364396). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). RNA-binding is semi-sequence specific (PubMed:17036044). {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:17036044, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:26876937}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sequence-specific mRNA binding|
|phospholipase binding|
|mRNA cis splicing, via spliceosome|
|regulation of alternative mRNA splicing, via spliceosome|
|mRNA 3-end processing|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|regulation of mRNA splicing, via spliceosome|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|regulation of RNA splicing|
|regulation of mRNA processing|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|intracellular protein transport|
|cellular response to cytokine stimulus|
|response to cytokine|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.07|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.01|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.96|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.95|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.88|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.81|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.73|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.72|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.72|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.75|
|[[:results:exp136|MS094 2μM R03 exp136]]|1.75|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.8|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.88|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.96|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|2.02|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.07|
|[[:results:exp187|proTAME 5μM R04 exp187]]|2.09|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.485|
|[[:human genes:v:vps28|VPS28]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 717/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|24/25|
|breast|31/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|1/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1393
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRSF3 Expression in NALM6 Cells: 9.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>