SRSF5 [The Human Chemical-Genetic Interaction Map Project]

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======= SRSF5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SRSF5
  * **<color #00a2e8>Official Name</color>**: serine and arginine rich splicing factor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6430|6430]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13243|Q13243]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SRSF5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SRSF5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600914|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein kinase B binding|
|liver regeneration|
|mRNA splice site selection|
|mRNA cis splicing, via spliceosome|
|positive regulation of RNA splicing|
|spliceosomal complex assembly|
|regulation of alternative mRNA splicing, via spliceosome|
|animal organ regeneration|
|mRNA 3-end processing|
|regulation of mRNA splicing, via spliceosome|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|liver development|
|RNA export from nucleus|
|hepaticobiliary system development|
|RNA 3-end processing|
|regulation of RNA splicing|
|regulation of mRNA processing|
|protein export from nucleus|
|mRNA transport|
|regeneration|
|nuclear export|
|cellular response to insulin stimulus|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|response to insulin|
|ribonucleoprotein complex assembly|
|nucleobase-containing compound transport|
|ribonucleoprotein complex subunit organization|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|cellular response to peptide hormone stimulus|
|nuclear transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|cellular response to peptide|
|regulation of mRNA metabolic process|
|response to peptide hormone|
|RNA splicing|
|nuclear speck|
|gland development|
|ribonucleoprotein complex biogenesis|
|response to peptide|
|mRNA processing|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA processing|
|response to hormone|
|intracellular protein transport|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|RNA binding|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.54|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.39|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.23|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.08|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.07|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.86|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.85|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.82|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.75|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.75|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.72|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.72|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|3.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6923
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SRSF5 Expression in NALM6 Cells: 8.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>