SSC5D [The Human Chemical-Genetic Interaction Map Project]

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======= SSC5D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SSC5D
  * **<color #00a2e8>Official Name</color>**: scavenger receptor cysteine rich family member with 5 domains
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=284297|284297]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A1L4H1|A1L4H1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SSC5D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SSC5D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618194|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SRCR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of bacterial lipoprotein|
|negative regulation of interleukin-8 secretion|
|response to bacterial lipoprotein|
|detection of molecule of bacterial origin|
|detection of bacterium|
|detection of other organism|
|negative regulation of interleukin-8 production|
|detection of external biotic stimulus|
|detection of biotic stimulus|
|regulation of interleukin-8 secretion|
|laminin binding|
|fibronectin binding|
|extracellular matrix binding|
|scavenger receptor activity|
|negative regulation of cytokine secretion|
|regulation of interleukin-8 production|
|defense response to Gram-negative bacterium|
|defense response to Gram-positive bacterium|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|negative regulation of secretion|
|negative regulation of cytokine production|
|response to molecule of bacterial origin|
|defense response to bacterium|
|collagen-containing extracellular matrix|
|external side of plasma membrane|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|detection of chemical stimulus|
|endocytosis|
|import into cell|
|response to bacterium|
|detection of stimulus|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|innate immune response|
|regulation of secretion|
|defense response to other organism|
|regulation of protein localization|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|extracellular space|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6385
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SSC5D Expression in NALM6 Cells: 0.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>