SSH1 [The Human Chemical-Genetic Interaction Map Project]

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======= SSH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SSH1
  * **<color #00a2e8>Official Name</color>**: slingshot protein phosphatase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54434|54434]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WYL5|Q8WYL5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SSH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SSH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606778|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12684437, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:14645219, ECO:0000269|PubMed:15056216, ECO:0000269|PubMed:15159416, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:16230460}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEK C|
|DSPc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of AMPA glutamate receptor clustering|
|regulation of AMPA glutamate receptor clustering|
|regulation of glutamate receptor clustering|
|positive regulation of postsynaptic membrane organization|
|positive regulation of receptor clustering|
|excitatory chemical synaptic transmission|
|positive regulation of synaptic plasticity|
|regulation of receptor clustering|
|regulation of postsynaptic membrane organization|
|positive regulation of vascular associated smooth muscle cell migration|
|cellular response to ATP|
|regulation of vascular associated smooth muscle cell migration|
|positive regulation of excitatory postsynaptic potential|
|response to ATP|
|positive regulation of smooth muscle cell migration|
|modulation of excitatory postsynaptic potential|
|phosphoprotein phosphatase activity|
|protein tyrosine/serine/threonine phosphatase activity|
|cleavage furrow|
|regulation of smooth muscle cell migration|
|positive regulation of nervous system process|
|cellular response to nutrient|
|positive regulation of neuron death|
|regulation of postsynapse organization|
|protein tyrosine phosphatase activity|
|peptidyl-tyrosine dephosphorylation|
|positive regulation of protein localization to membrane|
|growth cone|
|response to organophosphorus|
|regulation of nervous system process|
|positive regulation of synaptic transmission|
|response to purine-containing compound|
|midbody|
|lamellipodium|
|regulation of synaptic plasticity|
|regulation of protein localization to membrane|
|protein dephosphorylation|
|response to nutrient|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|actin binding|
|dephosphorylation|
|regulation of neuron death|
|positive regulation of cellular protein localization|
|cellular response to external stimulus|
|cytoskeleton|
|cellular response to drug|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|actin cytoskeleton organization|
|response to nutrient levels|
|positive regulation of cell migration|
|positive regulation of cell motility|
|response to extracellular stimulus|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|positive regulation of locomotion|
|actin filament-based process|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|positive regulation of cell death|
|cell morphogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cytoskeleton organization|
|cell-cell signaling|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10147
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SSH1 Expression in NALM6 Cells: 5.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>