SSR3 [The Human Chemical-Genetic Interaction Map Project]

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======= SSR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SSR3
  * **<color #00a2e8>Official Name</color>**: signal sequence receptor subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6747|6747]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNL2|Q9UNL2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SSR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SSR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606213|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TRAP-gamma|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SRP-dependent cotranslational protein targeting to membrane|
|cotranslational protein targeting to membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|protein localization to endoplasmic reticulum|
|protein targeting to membrane|
|establishment of protein localization to membrane|
|protein targeting|
|establishment of protein localization to organelle|
|protein localization to membrane|
|protein localization to organelle|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|endoplasmic reticulum|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.71|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.71|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.79|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.82|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.85|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.86|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.87|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.05|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.19|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.41|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:ssr2|SSR2]]|0.486|
|[[:human genes:s:ssr1|SSR1]]|0.461|
|[[:human genes:c:cd79b|CD79B]]|0.459|
|[[:human genes:r:rhoh|RHOH]]|0.446|
|[[:human genes:e:ergic1|ERGIC1]]|0.438|
|[[:human genes:c:cd79a|CD79A]]|0.433|
|[[:human genes:c:cd19|CD19]]|0.422|
|[[:human genes:s:syk|SYK]]|0.416|
|[[:human genes:p:pds5b|PDS5B]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10715
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SSR3 Expression in NALM6 Cells: 7.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>