STAC3 [The Human Chemical-Genetic Interaction Map Project]

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======= STAC3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STAC3
  * **<color #00a2e8>Official Name</color>**: SH3 and cysteine rich domain 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=246329|246329]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96MF2|Q96MF2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STAC3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STAC3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615521|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a component of the excitation-contraction coupling machinery of muscles. This protein is a member of the Stac gene family and contains an N-terminal cysteine-rich domain and two SH3 domains. Mutations in this gene are a cause of Native American myopathy. [provided by RefSeq, Nov 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels (PubMed:23736855, PubMed:29078335). Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity). Slows down the inactivation rate of the calcium channel CACNA1C (in vitro) (PubMed:29078335). {ECO:0000250|UniProtKB:Q8BZ71, ECO:0000269|PubMed:23736855, ECO:0000269|PubMed:29078335}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|C1 1|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of voltage-gated calcium channel activity|
|skeletal muscle fiber development|
|voltage-gated calcium channel complex|
|myotube cell development|
|skeletal muscle contraction|
|neuromuscular synaptic transmission|
|regulation of voltage-gated calcium channel activity|
|positive regulation of calcium ion transmembrane transporter activity|
|T-tubule|
|musculoskeletal movement|
|multicellular organismal movement|
|positive regulation of protein localization to plasma membrane|
|myotube differentiation|
|muscle fiber development|
|extrinsic component of cytoplasmic side of plasma membrane|
|positive regulation of protein localization to cell periphery|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|regulation of calcium ion transmembrane transporter activity|
|regulation of protein localization to plasma membrane|
|positive regulation of ion transmembrane transporter activity|
|striated muscle contraction|
|positive regulation of transporter activity|
|regulation of protein localization to cell periphery|
|positive regulation of calcium ion transport|
|positive regulation of protein localization to membrane|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|striated muscle cell development|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|muscle cell development|
|positive regulation of ion transmembrane transport|
|regulation of cation channel activity|
|regulation of protein localization to membrane|
|striated muscle cell differentiation|
|positive regulation of transmembrane transport|
|muscle cell differentiation|
|regulation of calcium ion transport|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|positive regulation of cellular protein localization|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|synaptic signaling|
|muscle structure development|
|regulation of ion transmembrane transport|
|regulation of cellular protein localization|
|regulation of transmembrane transport|
|regulation of ion transport|
|regulation of cellular localization|
|positive regulation of transport|
|regulation of protein localization|
|identical protein binding|
|cell-cell signaling|
|cell development|
|intracellular signal transduction|
|tissue development|
|positive regulation of molecular function|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.98|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.93|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.78|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.82|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.85|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4721
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STAC3 Expression in NALM6 Cells: 3.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>