STAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= STAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STAP1
  * **<color #00a2e8>Official Name</color>**: signal transducing adaptor family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26228|26228]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULZ2|Q9ULZ2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604298|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC. {ECO:0000269|PubMed:10518561}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of microglial cell migration|
|negative regulation of macrophage colony-stimulating factor signaling pathway|
|negative regulation of response to macrophage colony-stimulating factor|
|negative regulation of cellular response to macrophage colony-stimulating factor stimulus|
|regulation of microglial cell mediated cytotoxicity|
|macrophage colony-stimulating factor receptor binding|
|regulation of macrophage colony-stimulating factor signaling pathway|
|positive regulation of microglial cell mediated cytotoxicity|
|negative regulation of glial cell migration|
|negative regulation of ruffle assembly|
|regulation of cellular response to macrophage colony-stimulating factor stimulus|
|regulation of response to macrophage colony-stimulating factor|
|positive regulation of non-membrane spanning protein tyrosine kinase activity|
|negative regulation of macrophage chemotaxis|
|regulation of microglial cell migration|
|regulation of non-membrane spanning protein tyrosine kinase activity|
|positive regulation of microglial cell activation|
|positive regulation of B cell receptor signaling pathway|
|negative regulation of macrophage migration|
|positive regulation of phagocytosis, engulfment|
|transmembrane receptor protein tyrosine kinase adaptor activity|
|positive regulation of membrane invagination|
|positive regulation of neuroinflammatory response|
|regulation of phagocytosis, engulfment|
|regulation of glial cell migration|
|regulation of membrane invagination|
|negative regulation of leukocyte chemotaxis|
|regulation of microglial cell activation|
|positive regulation of actin cytoskeleton reorganization|
|positive regulation of antigen receptor-mediated signaling pathway|
|positive regulation of macrophage activation|
|negative regulation of plasma membrane bounded cell projection assembly|
|regulation of B cell receptor signaling pathway|
|regulation of macrophage chemotaxis|
|regulation of ruffle assembly|
|regulation of neuroinflammatory response|
|regulation of macrophage migration|
|regulation of actin cytoskeleton reorganization|
|phosphotyrosine residue binding|
|negative regulation of gliogenesis|
|negative regulation of leukocyte migration|
|regulation of macrophage activation|
|SH3/SH2 adaptor activity|
|positive regulation of leukocyte mediated cytotoxicity|
|positive regulation of protein tyrosine kinase activity|
|negative regulation of chemotaxis|
|negative regulation of cytokine-mediated signaling pathway|
|regulation of antigen receptor-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|positive regulation of cell killing|
|positive regulation of phagocytosis|
|regulation of leukocyte mediated cytotoxicity|
|regulation of protein tyrosine kinase activity|
|regulation of phagocytosis|
|positive regulation of endocytosis|
|regulation of cell killing|
|phospholipid binding|
|regulation of leukocyte chemotaxis|
|regulation of gliogenesis|
|positive regulation of inflammatory response|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|negative regulation of cell projection organization|
|cellular response to lipopolysaccharide|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular response to molecule of bacterial origin|
|regulation of leukocyte migration|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of endocytosis|
|regulation of chemotaxis|
|cellular response to biotic stimulus|
|positive regulation of cytoskeleton organization|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of neurogenesis|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|response to lipopolysaccharide|
|negative regulation of locomotion|
|response to molecule of bacterial origin|
|negative regulation of cell development|
|regulation of inflammatory response|
|regulation of actin cytoskeleton organization|
|negative regulation of response to external stimulus|
|regulation of actin filament-based process|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|protein kinase binding|
|positive regulation of defense response|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cellular response to lipid|
|positive regulation of protein kinase activity|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|positive regulation of kinase activity|
|protein-containing complex|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|positive regulation of organelle organization|
|regulation of cell activation|
|positive regulation of transferase activity|
|intracellular membrane-bounded organelle|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of defense response|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15243
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STAP1 Expression in NALM6 Cells: 6.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>