STAT5A [The Human Chemical-Genetic Interaction Map Project]

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======= STAT5A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STAT5A
  * **<color #00a2e8>Official Name</color>**: signal transducer and activator of transcription 5A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6776|6776]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42229|P42229]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STAT5A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STAT5A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601511|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. {ECO:0000269|PubMed:15534001}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|STAT bind|
|SH2|
|STAT int|
|STAT alpha|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alkanesulfonate metabolic process|
|reelin-mediated signaling pathway|
|taurine metabolic process|
|interleukin-9-mediated signaling pathway|
|cellular response to interleukin-9|
|response to interleukin-9|
|interleukin-2-mediated signaling pathway|
|cellular response to interleukin-2|
|response to interleukin-2|
|cellular response to interleukin-15|
|interleukin-15-mediated signaling pathway|
|growth hormone receptor signaling pathway via JAK-STAT|
|response to interleukin-15|
|interleukin-7-mediated signaling pathway|
|growth hormone receptor signaling pathway|
|cellular response to growth hormone stimulus|
|cellular response to interleukin-7|
|response to interleukin-7|
|response to growth hormone|
|receptor signaling pathway via JAK-STAT|
|receptor signaling pathway via STAT|
|lactation|
|positive regulation of blood vessel endothelial cell migration|
|regulation of multicellular organism growth|
|body fluid secretion|
|regulation of blood vessel endothelial cell migration|
|positive regulation of endothelial cell proliferation|
|positive regulation of endothelial cell migration|
|mammary gland development|
|regulation of endothelial cell proliferation|
|xenobiotic metabolic process|
|positive regulation of epithelial cell migration|
|regulation of endothelial cell migration|
|cellular response to xenobiotic stimulus|
|positive regulation of epithelial cell proliferation|
|regulation of epithelial cell migration|
|cellular response to peptide hormone stimulus|
|response to xenobiotic stimulus|
|cellular response to peptide|
|regulation of developmental growth|
|regulation of epithelial cell proliferation|
|sulfur compound metabolic process|
|response to peptide hormone|
|gland development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|response to peptide|
|regulation of body fluid levels|
|positive regulation of cell migration|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|regulation of growth|
|cytokine-mediated signaling pathway|
|DNA-binding transcription factor activity|
|enzyme linked receptor protein signaling pathway|
|regulation of cell migration|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|secretion|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|defense response|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10840
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STAT5A Expression in NALM6 Cells: 1.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>