STAT5B [The Human Chemical-Genetic Interaction Map Project]

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======= STAT5B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STAT5B
  * **<color #00a2e8>Official Name</color>**: signal transducer and activator of transcription 5B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6777|6777]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P51692|P51692]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STAT5B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STAT5B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604260|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. {ECO:0000269|PubMed:20702587, ECO:0000269|PubMed:8732682}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH2|
|STAT bind|
|STAT int|
|STAT alpha|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|taurine metabolic process|
|alkanesulfonate metabolic process|
|cellular response to interleukin-9|
|interleukin-9-mediated signaling pathway|
|response to interleukin-9|
|interleukin-2-mediated signaling pathway|
|cellular response to interleukin-2|
|interleukin-15-mediated signaling pathway|
|cellular response to interleukin-15|
|response to interleukin-2|
|response to interleukin-15|
|growth hormone receptor signaling pathway via JAK-STAT|
|glucocorticoid receptor binding|
|interleukin-7-mediated signaling pathway|
|growth hormone receptor signaling pathway|
|cellular response to growth hormone stimulus|
|response to interleukin-7|
|cellular response to interleukin-7|
|positive regulation of erythrocyte differentiation|
|response to growth hormone|
|receptor signaling pathway via JAK-STAT|
|receptor signaling pathway via STAT|
|cellular response to epidermal growth factor stimulus|
|regulation of erythrocyte differentiation|
|response to epidermal growth factor|
|regulation of multicellular organism growth|
|positive regulation of myeloid cell differentiation|
|xenobiotic metabolic process|
|response to estradiol|
|protein dimerization activity|
|cellular response to xenobiotic stimulus|
|positive regulation of hemopoiesis|
|regulation of myeloid cell differentiation|
|cellular response to peptide hormone stimulus|
|response to xenobiotic stimulus|
|cellular response to peptide|
|regulation of developmental growth|
|sulfur compound metabolic process|
|response to peptide hormone|
|chromatin binding|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|response to peptide|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|regulation of growth|
|cytokine-mediated signaling pathway|
|DNA-binding transcription factor activity|
|enzyme linked receptor protein signaling pathway|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|positive regulation of cell differentiation|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to cytokine|
|positive regulation of immune system process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|defense response|
|positive regulation of developmental process|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.81|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|4/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15024
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STAT5B Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>