STAU1 [The Human Chemical-Genetic Interaction Map Project]

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======= STAU1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STAU1
  * **<color #00a2e8>Official Name</color>**: staufen double-stranded RNA binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6780|6780]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95793|O95793]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STAU1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STAU1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601716|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|dsrm|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation by virus of viral protein levels in host cell|
|regulation by virus of viral protein levels in host cell|
|modification of postsynaptic structure|
|modification of synaptic structure|
|protein phosphatase 1 binding|
|positive regulation of long-term synaptic potentiation|
|microtubule associated complex|
|positive regulation of viral genome replication|
|regulation of long-term synaptic potentiation|
|rough endoplasmic reticulum|
|positive regulation of viral life cycle|
|cytoplasmic stress granule|
|cytoplasmic ribonucleoprotein granule|
|double-stranded RNA binding|
|cell body|
|regulation of viral genome replication|
|positive regulation of viral process|
|regulation of viral life cycle|
|positive regulation of synaptic transmission|
|regulation of synaptic plasticity|
|regulation of viral process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|cellular response to oxidative stress|
|synapse organization|
|glutamatergic synapse|
|neuronal cell body|
|response to oxidative stress|
|dendrite|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of multi-organism process|
|viral process|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|endoplasmic reticulum|
|chemical homeostasis|
|RNA binding|
|homeostatic process|
|cellular response to stress|
|positive regulation of cell communication|
|positive regulation of signaling|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.74|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.76|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.78|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.81|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.84|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.87|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.9|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.99|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.13|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.18|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.26|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.33|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.37|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.41|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.46|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.51|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.52|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.56|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|3|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.06|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|3.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bak1|BAK1]]|0.603|
|[[:human genes:m:march5|MARCH5]]|0.585|
|[[:human genes:a:apaf1|APAF1]]|0.539|
|[[:human genes:u:ubqln1|UBQLN1]]|0.522|
|[[:human genes:d:diablo|DIABLO]]|0.52|
|[[:human genes:c:casp9|CASP9]]|0.518|
|[[:human genes:c:cycs|CYCS]]|0.511|
|[[:human genes:v:vdac2|VDAC2]]|0.507|
|[[:human genes:h:hars|HARS]]|0.506|
|[[:human genes:p:plaa|PLAA]]|0.503|
|[[:human genes:g:gabpa|GABPA]]|0.462|
|[[:human genes:h:hccs|HCCS]]|0.458|
|[[:human genes:s:serf2|SERF2]]|0.44|
|[[:human genes:m:mfn1|MFN1]]|0.438|
|[[:human genes:f:faf2|FAF2]]|0.436|
|[[:human genes:k:kctd5|KCTD5]]|0.426|
|[[:human genes:m:mlst8|MLST8]]|0.425|
|[[:human genes:d:dohh|DOHH]]|0.411|
|[[:human genes:m:mtor|MTOR]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18240
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STAU1 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>