STIM2 [The Human Chemical-Genetic Interaction Map Project]

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======= STIM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STIM2
  * **<color #00a2e8>Official Name</color>**: stromal interaction molecule 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57620|57620]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P246|Q9P246]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STIM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STIM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610841|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation of store-operated calcium channel activity|
|positive regulation of store-operated calcium channel activity|
|store-operated calcium entry|
|regulation of store-operated calcium channel activity|
|store-operated calcium channel activity|
|calcium channel regulator activity|
|positive regulation of calcium ion transmembrane transporter activity|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|regulation of calcium ion transmembrane transporter activity|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|positive regulation of calcium ion transport|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|regulation of cation channel activity|
|calcium ion transmembrane transport|
|positive regulation of transmembrane transport|
|regulation of calcium ion transport|
|calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|positive regulation of transport|
|endoplasmic reticulum|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|homeostatic process|
|positive regulation of molecular function|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-2.26|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.25|
|[[:results:exp115|A-366 10μM R03 exp115]]|-2.05|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.74|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.75|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.91|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|3.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5793
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STIM2 Expression in NALM6 Cells: 7.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>