STK3 [The Human Chemical-Genetic Interaction Map Project]

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======= STK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STK3
  * **<color #00a2e8>Official Name</color>**: serine/threonine kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6788|6788]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13188|Q13188]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=STK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20STK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605030|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38. {ECO:0000250|UniProtKB:Q9JI10, ECO:0000269|PubMed:15688006, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:20212043, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:28087714, ECO:0000269|PubMed:8566796, ECO:0000269|PubMed:8816758}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
|Mst1 SARAH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cell differentiation involved in embryonic placenta development|
|primitive hemopoiesis|
|hepatocyte apoptotic process|
|endocardium development|
|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|embryonic hemopoiesis|
|cell differentiation involved in embryonic placenta development|
|epithelial cell apoptotic process|
|hippo signaling|
|protein serine/threonine kinase activator activity|
|negative regulation of organ growth|
|positive regulation of extrinsic apoptotic signaling pathway|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of fat cell differentiation|
|embryonic placenta development|
|regulation of organ growth|
|positive regulation of protein binding|
|negative regulation of developmental growth|
|neural tube formation|
|regulation of fat cell differentiation|
|embryonic epithelial tube formation|
|regulation of embryonic development|
|epithelial tube formation|
|positive regulation of JNK cascade|
|stress-activated protein kinase signaling cascade|
|morphogenesis of embryonic epithelium|
|tube formation|
|placenta development|
|regulation of extrinsic apoptotic signaling pathway|
|protein dimerization activity|
|neural tube development|
|regulation of reproductive process|
|positive regulation of protein kinase B signaling|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|negative regulation of canonical Wnt signaling pathway|
|positive regulation of apoptotic signaling pathway|
|protein stabilization|
|positive regulation of binding|
|regulation of JNK cascade|
|negative regulation of Wnt signaling pathway|
|magnesium ion binding|
|regulation of protein binding|
|regulation of protein kinase B signaling|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|protein kinase activity|
|negative regulation of growth|
|positive regulation of DNA-binding transcription factor activity|
|regulation of canonical Wnt signaling pathway|
|regulation of protein stability|
|epithelial tube morphogenesis|
|activation of protein kinase activity|
|regulation of developmental growth|
|positive regulation of protein serine/threonine kinase activity|
|regulation of Wnt signaling pathway|
|protein serine/threonine kinase activity|
|in utero embryonic development|
|regulation of binding|
|signal transduction by protein phosphorylation|
|regulation of apoptotic signaling pathway|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|regulation of protein serine/threonine kinase activity|
|heart development|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|hemopoiesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|protein-containing complex|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|tube development|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|apoptotic process|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|embryo development|
|central nervous system development|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|positive regulation of phosphorylation|
|identical protein binding|
|cell death|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|-2.42|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-1.94|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.78|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.71|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.75|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16944
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='STK3 Expression in NALM6 Cells: 4.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>